Abstract
Abstract 11720: Loss of Vascular Smooth-Muscle Activity During Moderate Physical Activity as a Hallmark of Aging in Human Subjects
Circulation (New York, N.Y.), Vol.144(Suppl_1), p.A11720
11/16/2021
DOI: 10.1161/circ.144.suppl_1.11720
Abstract
Studies have shown a higher risk of adverse outcomes after cardiac surgery in patients with reduced complexity of arterial-pressure dynamics (APD). We hypothesized that this effect is caused by age-related loss of vascular smooth-muscle activity (VSMA). This hypothesis was tested using data from 30 humans and a validated, large-scale theoretical model of circulation with VSMA blocked (T-model). The results were also verified in a realistic physical model of circulation (P-model, Fig.1).
Methods:
ECG and APD data were recorded using a high-fidelity system (APEX, PinMed, Inc.) during moderate physical activity (handgrip followed by leg lifts) in 30 subjects (age: 46±10y, 53% female; pressure ranges for systolic, diastolic, and mean: 90-210, 49-116, and 67-147mm, respectively).
Results:
T-model accurately predicted APD in older subjects ≥48y (n=13, r
2
=0.74; Fig.2); this effect was preserved in both females and males, but not in younger subjects (n=17, r
2
=0.13). The difference between the older and younger subjects was pronounced (40%) and significant (p=0.01, F-test). In P-model, changes in cardiac force produced changes in central arterial pressure that were in excellent agreement with those observed in humans ≥48y (r
2
=0.93, Fig.3).
Conclusions:
Loss of VSMA during physical activity could serve as an important prognostic/diagnostic indicator of cardiovascular aging and disease.
Details
- Title: Subtitle
- Abstract 11720: Loss of Vascular Smooth-Muscle Activity During Moderate Physical Activity as a Hallmark of Aging in Human Subjects
- Creators
- Vladimir Shusterman - University of IowaStacy Hoffman - PinMed, Inc., Pittsburgh, PABarry London - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.144(Suppl_1), p.A11720
- DOI
- 10.1161/circ.144.suppl_1.11720
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/16/2021
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984302190902771
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