Abstract
Abstract 11891: Adverse Childhood Experiences are Associated With Elevated Blood Pressure and Disturbed Sleep in the First Trimester of Pregnancy in Apparently Healthy, Young Adult Women
Circulation (New York, N.Y.), Vol.146(S_1), p.A11891
11/08/2022
Abstract
Byline: Nathaniel D Jenkins, Health and Human Physiology, Univ of Iowa, Iowa City, IA; Christopher E Kline, Health and Human Development, UNIVERSITY OF PITTSBURGH, Pittsburgh, PA; Bethany Barone Gibbs, West Virginia Univ, Morgantown, WV; Janet M Catov, UNIVERSITY OF PITTSBURGH, Pittsburgh, PA; Maisa Feghali, Obstetrics, Gynecology, and Reproductive Sciences, UPMC Magee-Womens Hosp, Pittsburgh, PA; Mark K Santillan, UNIVERSITY IOWA CARVER COLL MED, Iowa City, IA; Emily B Thomas, Psychology and Brain Sciences, Univ of Iowa, Iowa City, IA; Melissa A Jones, Health and Human Physiology, Univ of Iowa, Iowa City, IA; Kara M Whitaker, UNIVERSITY OF IOWA, Iowa City, IA Introduction: Adverse childhood experiences (ACEs) are potentially traumatic psychosocial stressors that occur in early life, such as abuse, neglect, and household dysfunction. We hypothesize that ACEs are an underlying risk factor for disturbed sleep and hypertension in pregnancy, which is a major cause of maternal-fetal morbidity and mortality. Hypothesis: In young adult women, ACE exposure will be positively associated with first trimester systolic (SBP), diastolic blood pressure (DBP), and wakefulness after sleep onset (WASO), and inversely associated with sleep efficiency (SE). Further, ACE exposure will be associated with greater odds of first trimester elevated or stage 1 hypertension (ES1H). Methods: Data were obtained at 10-12 weeks of gestation from 142 pregnant women who were enrolled in an ongoing, clinical cohort study in Iowa City and Pittsburgh. Participants were 18-45 y of age, had a BMI <40 kg/m2, and could not be taking medications or receiving treatment for sleep or cardiometabolic disorders such as chronic hypertension or diabetes. BP was assessed in accordance with AHA recommendations. Actigraphy was used to assess WASO and SE over [greater than or equal] 5 nights. ACE scores were log transformed and correlations were used to examine associations between ACE exposure and SBP, DBP, WASO and SE. Logistic regression was used to examine the association of ACE exposure with the probability of ES1H in an unadjusted model (model 1) and a model adjusted for age, race, ethnicity, BMI, and depressive symptoms (model 2). Results: 56% reported exposure to [greater than or equal] 1 ACE, and 28% reported exposure to [greater than or equal] 3. ACE exposure was positively related to SBP (r = 0.17, p = 0.04), DBP (r = 0.21, p = 0.01), and WASO (Îü = 0.21, p = 0.01), and negatively associated with SE (Îü = -0.22, p = 0.009). ACE exposure was associated with greater odds of first trimester ES1H in model 1 (OR = 2.73, 95% CI = 1.36 - 5.50; p = 0.005) and model 2 (OR = 2.44, 95% CI = 1.07 - 5.56; p = 0.03). Conclusions: ACEs represent an important risk factor for elevated BP and disturbed sleep in pregnancy. Large cohort studies are needed to understand the links among ACE exposure, sleep, resilience factors and hypertensive risk in pregnancy to provide information for developing targeted interventions to improve maternal-fetal cardiovascular health.
Details
- Title: Subtitle
- Abstract 11891: Adverse Childhood Experiences are Associated With Elevated Blood Pressure and Disturbed Sleep in the First Trimester of Pregnancy in Apparently Healthy, Young Adult Women
- Creators
- Nathaniel D JenkinsChristopher E KlineBethany Barone GibbsJanet M CatovMaisa FeghaliMark K SantillanEmily B Thomas
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.146(S_1), p.A11891
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- Lippincott Williams & Wilkins, WK Health
- Language
- English
- Date published
- 11/08/2022
- Description audience
- Professional
- Academic Unit
- Psychological and Brain Sciences; Center for Social Science Innovation; Obstetrics and Gynecology; Injury Prevention Research Center; Health, Sport, and Human Physiology
- Record Identifier
- 9984354111202771
Metrics
31 Record Views