Abstract
Abstract 13650: Prognostic Significance Of Atrial Arrhythmias In Pulmonary Hypertension: A Meta-analysis
Circulation (New York, N.Y.), Vol.144(Suppl_1), pp.A13650-A13650
11/16/2021
DOI: 10.1161/circ.144.suppl_1.13650
Abstract
Background: Atrial arrhythmias (AA: atrial tachycardia, atrial fibrillation, and atrial flutter) are common in patients (pts) with pulmonary hypertension (PH) due to increased right atrial pressure and increased sympathetic tone. AA occurrence in PH may lead to clinical deterioration and affect prognosis. Whether mortality in pts with PH is increased with comorbid AA compared to those without AA is not well established. The aim of this meta-analysis is to investigate published evidence of AA role in predicting outcomes of pts with PH.
Methods and Results: We searched available literature across PubMed, EMBASE and Cochrane Library databases, and 11 observational studies with a pooled population of 2763 pts were included in this meta-analysis. Among the pooled population of pts with PH, there were 561 pts with AA (20%). We compared the outcomes of all-cause mortality among PH pts with and without AA. All-cause mortality was significantly higher in PH pts with AA compared to those without AA (odds ratio, OR=1.78; 95% confidence interval, 1.46-2.18; P<0.01). No AA-driven differences were found among WHO groups of PH (p=0.75) or gender (p=0.42).
Conclusion: Our results indicate that overall mortality is higher in PH pts presenting with AA as compared to those without AA. Further research needed in evaluating the effect of AA therapy with restoration and maintenance of sinus rhythm on mortality in PH.
Details
- Title: Subtitle
- Abstract 13650: Prognostic Significance Of Atrial Arrhythmias In Pulmonary Hypertension: A Meta-analysis
- Creators
- Joseph Sebastian - Wayne State UniversityDaniel Deneve - Wayne State UniversitySreya SebastianSwara Sarvepalli - Central Michigan UniversityAbdel-Rhman Mohamed - Wayne State UniversityKatherine Akers - Katherine HospitalRamanjit Kaur - Wayne State UniversityAiden Abidov - John D. Dingell VA Med Cntr/Wayne State Univ, Detroit, MI
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.144(Suppl_1), pp.A13650-A13650
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/circ.144.suppl_1.13650
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/16/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845213102771
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