Abstract
Abstract 14021: A Meta Analysis for Clinical Outcomes of Transcatheter Aortic Valve Replacement in Patients With Bicuspid versus Tricuspid Aortic Valves Using Balloon Expandable versus Self Expanding Valves
Circulation (New York, N.Y.), Vol.146(Suppl_1), pp.A14021-A14021
11/08/2022
DOI: 10.1161/circ.146.suppl_1.14021
Abstract
IntroductionOver the past decade, several next generation transcatheter aortic valve replacement (TAVR) devices have been developed with the aim of improving patients’ outcomes. Bicuspid aortic valves (BAVs) are an emerging issue in TAVR practice. The goal of this study was to compare clinical outcomes of TAVR using balloon-expandable (BE) versus self-expanding (SE) transcatheter heart valves in patients with BAV vs tricuspid aortic valve (TAV). MethodsWe searched PubMed, Cochrane and Embase databases systematically for relevant studies from inception to March 2022. The primary focus was 1-year all-cause mortality. Additional outcomes included short term (30-days) all-cause mortality, cardiovascular mortality, stroke, major/life threatening bleeding, permanent pacemaker (PPM) implantation and major vascular complications. ResultsThere were 28 studies with a total 346,033 patients who underwent TAVR, 17,835 of which had BAV stenosis. In the BE group, there was a statistically lower risk of mortality of TAVR in the BAV when compared to the TAV (OR 0.69 [95% CI 0.49-0.97]; p=0.03). In terms of short-term outcomes of BE group, the risks of all-cause mortality, stroke, PPM implantation, major bleeding, and major vascular complications were all similar between the two arms. In the SE group, there were not statistically significant in the clinical outcomes between patients in BAV and TAV. ConclusionsThe use of balloon-expandable valves in TAVR was associated with a lower risk of 1-year mortality in patients with BAV compared to patients with TAV. These data support the need for a randomized trial to compare the balloon-expandable valves in BAV patients.
Details
- Title: Subtitle
- Abstract 14021: A Meta Analysis for Clinical Outcomes of Transcatheter Aortic Valve Replacement in Patients With Bicuspid versus Tricuspid Aortic Valves Using Balloon Expandable versus Self Expanding Valves
- Creators
- Enhua Wang - Michigan State UniversityYasser Radwan - Lansing, MIMohammad F Salam - Battle Creek VA Medical CenterKhalid Saeed Al-Asad - Michigan State UniversityAdnan Halboni - Wayne State UniversityAbdullah Al-abcha - Michigan State UniversityYehia Saleh - Houston MethodistAbela George - Michigan State University
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.146(Suppl_1), pp.A14021-A14021
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/circ.146.suppl_1.14021
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/08/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984757275802771
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