Abstract
Abstract 143: Increased Contrast Enhancement of the Parent Vessel of Unruptured Intracranial Aneurysms in 7T Magnetic Resonance Imaging
Stroke (1970), Vol.51(Suppl_1)
02/2020
DOI: 10.1161/str.51.suppl_1.143
Abstract
Background: Aneurysm formation and growth might be explained by a local inflammatory/vasculopathic process that debilitates the wall of the parent artery. Recently, the presence of aneurysm enhancement on high-resolution vessel wall imaging (HR-VWI) has been proposed as a surrogate for vessel wall inflammation. However, no studies have correlated circumferential aneurysm wall enhancement (CAWE) and aneurysm-to-pituitary enhancement ratio (CR stalk ) on HR-VWI with parent vessel enhancement (PVE) and reference vessel enhancement (RVE). Methods: Patients with unruptured intracranial aneurysms prospectively underwent HR-VWI using 7T MRI. CAWE, CR stalk , PVE and RVE were objectively analyzed by measuring signal intensity in T1 post-contrast sequences using manual 3D co-registration and segmentation of the vessel wall. CR stalk was calculated as the ratio of post-contrast CAWE over pituitary stalk enhancement. RVE was assessed in the mid-BA for aneurysms in the anterior circulation, and the MCA (M1 segment) for posterior circulation aneurysms. Correlation statistics were performed to find any significant association between CAWE, CR stalk , PVE and RVE. Results: Nineteen patients with 20 aneurysms were included. Mean age was 68.9 ± 9.9 years old, and 16 (84.2%) were women. Pearson and Spearman coefficients’ analyses demonstrated a strong positive correlation between post-contrast CAWE and PVE (0.72 and 0.73, both P <.001), whereas the correlation between post-contrast CAWE and RVE was low (both 0.47, P =.04). A stronger correlation was found between CR stalk and post-contrast PVE (Pearson = 0.82, Spearman = 0.71, both P <.001), while the correlation between CR stalk and post-contrast RVE was negligible (Pearson = 0.33, P =.15; Spearman = 0.38, P =.09). Conclusion: This HR-VWI study shows that the parent vessel of unruptured intracranial aneurysms enhances more with contrast than vessels located in other vascular territories. This finding suggests that a local inflammatory/vasculopathic process in the wall of the parent artery may lead to aneurysm formation.
Details
- Title: Subtitle
- Abstract 143: Increased Contrast Enhancement of the Parent Vessel of Unruptured Intracranial Aneurysms in 7T Magnetic Resonance Imaging
- Creators
- Jorge A Roa - Neurology and Neurosurgery, Univ of Iowa Hosps and Clinics, Iowa City, IAMario Zanaty - Neurosurgery, Univ of Iowa Hosps and Clinics, Iowa City, IACarlos Osorno-Cruz - Neurosurgery, Univ of Iowa Hosps and Clinics, Iowa City, IAAvery Pazour - Neurology, Univ of Iowa Hosps and Clinics, Iowa City, IADaizo Ishii - Neurosurgery, Univ of Iowa Hosps and Clinics, Iowa City, IASantiago Ortega-Gutierrez - Neurology, Neurosurgery and Radiology, Univ of Iowa Hosps and Clinics, Iowa City, IAVincent A Magnotta - Radiology, Univ of Iowa Hosps and Clinics, Iowa City, IADavid M Hasan - Neurosurgery, Univ of Iowa Hosps and Clinics, Iowa City, IAEdgar A Samaniego - Neurology, Neurosurgery and Radiology, Univ of Iowa Hosps and Clinics, Iowa City, IA
- Resource Type
- Abstract
- Publication Details
- Stroke (1970), Vol.51(Suppl_1)
- DOI
- 10.1161/str.51.suppl_1.143
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Radiology; Neurology; Iowa Neuroscience Institute; Otolaryngology; Psychiatry; Neurosurgery; Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984093890002771
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