Abstract
Abstract 14407: Clinical Outcomes of Transcatheter Aortic Valve Replacement in Patients With Bicuspid versus Tricuspid Aortic Valve Stenosis
Circulation (New York, N.Y.), Vol.146(Suppl_1), pp.A14407-A14407
11/08/2022
DOI: 10.1161/circ.146.suppl_1.14407
Abstract
IntroductionTranscatheter aortic valve replacement (TAVR) has proven to be safe and efficacious in patients with tricuspid aortic valve (TAV) stenosis. However, due to its anatomic complexity, bicuspid aortic valve (BAV) stenosis has been excluded from previous trials, and data remain limited regarding TAVR in this group of patients. MethodsWe searched the databases systematically for relevant studies from inception to March 2022. The primary focus was all-cause mortality at 1-year. Additional outcomes included 30-day mortality, 30-day stroke, and 30-day major vascular complications. ResultsWe included 28 studies with a total of 346,033 patients who underwent TAVR, of which 17,835 patients had BAV stenosis. The risks of 1-year mortality and 30-day major vascular complications were similar between the 2 groups. However, patients with BAV who underwent TAVR had a higher risk of 30-days mortality (BAV 2.3% vs TAV 2.2%, p=0.02) and 30-day stroke (BAV 2.2% vs TAV 1.8%, p=0.01). A subgroup analysis of 23,623 matched patients of whom 49.5% had BAV stenosis was performed. The risk of 1-year mortality was lower in patients with BAV compared to TAV (BAV 5.8% vs TAV 6.8%, p=0.009). Risks of 30-day mortality, and 30-day major vascular complication were similar between the two groups. However, the risk of 30-day stroke was higher in the BAV group (BAV 2.2% vs TAV 1.7%, p=0.02). ConclusionsIn our meta-analysis, among patients who underwent TAVR for aortic stenosis, there was no significant difference between BAV vs TAV in outcomes, except for higher risk of 30-days mortality and stroke. Among matched groups, patients with BAV stenosis undergoing TAVR had comparable outcomes to patients with TAV stenosis except for higher risk of stroke and lower risk of 1-year mortality in BAV group.More studies, specifically randomized trials, are still warranted to further assess efficacy, safety and reassure the long-term outcomes in this group of patients.
Details
- Title: Subtitle
- Abstract 14407: Clinical Outcomes of Transcatheter Aortic Valve Replacement in Patients With Bicuspid versus Tricuspid Aortic Valve Stenosis
- Creators
- Yasser Radwan - Michigan State UniversityEnhua Wang - Michigan State UniversityMohammad F Salam - Battle Creek VA Medical CenterKhalid Saeed Al-Asad - Michigan State UniversityAdnan Halboni - Wayne State UniversityAbdullah Al-abcha - Michigan State UniversityYehia Saleh - Houston Methodistgeorge Abela - East Lansing, MI
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.146(Suppl_1), pp.A14407-A14407
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/circ.146.suppl_1.14407
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/08/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984757159002771
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