Abstract
Abstract 14500: Physical Activity in Individuals With the Long Qt Syndrome: Baseline Data From the Lifestyle and Exercise in Long Qt Study (live Lqts)
Circulation (New York, N.Y.), Vol.142(Suppl_3), pp.A14500-A14500
11/17/2020
DOI: 10.1161/circ.142.suppl_3.14500
Abstract
Introduction:
The safety of vigorous exercise for individuals with appropriately-treated LQTS remains unproven, and physical activity practices in this population have not been described.
Methods:
LIVE-LQTS prospectively enrolled individuals age 8-60 years with overt LQTS or gene mutation carriers. Participants (or parents, for children) answered surveys describing activity patterns. Vigorous exercise was defined as
>
6 METS for
>
60 hours per year. Clinical and demographic data were derived from medical record review.
Results:
Among 1554 participants, 804 (52%) reported exercising vigorously, 473 of these competitively, 577 (37%) exercising at moderate, and 173 (11%) at low levels. Seven percent of those working describe jobs more active than walking, including 10 in protective services and 19 in sports/coaching. Over 90% are genotype positive, 57% are phenotype positive at rest and an additional 16% have exercise-induced QT prolongation. Forty four percent have had documented ventricular arrhythmias or syncope. Eighty-four percent are appropriately treated with either beta-blockers, ICD, and/or sympathectomy, although among beta-blocked patients, only 60% are on the most effective agents. Among adults, BMI was significantly lower among the vigorous exercisers.
Conclusion:
While the high percentage of vigorous exercisers seen in this study may not represent all patients with LQTS due to self-selection for study participation, many patients with LQTS are engaged in vigorous exercise or competitive athletics. Prospective follow up of this cohort is ongoing and will determine safety of vigorous exercise through comparison of arrhythmic outcomes in vigorous exercisers vs moderate/low level exercisers.
Details
- Title: Subtitle
- Abstract 14500: Physical Activity in Individuals With the Long Qt Syndrome: Baseline Data From the Lifestyle and Exercise in Long Qt Study (live Lqts)
- Creators
- Rachel J Lampert - YALE SCH OF MEDICINE, New Haven, CTSharlene Day - University of PennsylvaniaBradley S Marino - Highland Community College - IllinoisMatthew Burg - Yale Sch of Medicine, West Haven, CTBarbara Ainsworth - Arizona State UniversityMaite Tome - St Georges Hosp, London, United KingdomSusan P Etheridge - PCOS ECCLES BULIDING, Salt Lake Cty, UTDominic J Abrams - BOSTON CHILDRENS HOSPITAL, Boston, MAPeter F Aziz - Cleveland ClinicMarina Cerrone - New York University School of MedicineRichard J Czosek - CINCINNATI CHILDRENS HOSPITAL, Cincinnati, OHChristopher C Erickson - JOINT DIVISION OF PEDI OF CARDIO, Omaha, NEBelinda Gray - University of SydneyChristopher Johnsrude - University of LouisvillePrince J Kannankeril - VANDERBILT CHILDRENS HOSPITAL, Nashville, TNIan H Law - University of IowaRebecca McClellan - Johns Hopkins, Baltimore, MDSilvana M Molossi - BCM TEXAS CHILDRENS HOSPITAL, Houston, TXMarco V Perez - Stanford UniversityShubhayan Sanatani - British Columbia, Vancouver, CanadaMaully S Shah - Childrens Hosp of Philadelphia, Philadelphia, PAJonathan Skinner - University of AucklandJames S Ware - Imperial College LondonGregory G Webster - Lurie Childrens Hosp, Chicago, ILFangyong Li - YALE SCH OF MEDICINE, New Haven, CTLaura Simone - YALE SCH OF MEDICINE, New Haven, CTCheryl Barth - YALE SCH OF MEDICINE, New Haven, CTKim Harmon - University of WashingtonKevin Hall - YALE SCH OF MEDICINE, New Haven, CTBrian Olshansky - Mercy Medical Center North IowaMark Estes - University of PittsburghGordon F Tomaselli - Albert Einstein College of MedicineMark S Link - The University of Texas Southwestern Medical CenterElizabeth Saarel - Cleveland ClinicDavid S Cannom - Keck Medicine of USC, Los Angeles, CAMichael J Ackerman - Mayo Clinic
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.142(Suppl_3), pp.A14500-A14500
- DOI
- 10.1161/circ.142.suppl_3.14500
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/17/2020
- Academic Unit
- Internal Medicine; Stead Family Department of Pediatrics; Cardiology
- Record Identifier
- 9984354502602771
Metrics
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