Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample

Frederick B Rivera; Sonny Redula; Mara Bernadette Liston; Erika Ong; Nathan Ross Bantayan; Sarang Choi; Vikram Sharma; Gurleen Kaur; Fareed Moses M Collado; Annabelle S Volgman; Mamas Mamas

doi:10.1161/circ.148.suppl_1.14815

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Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample

Frederick B Rivera, Sonny Redula, Mara Bernadette Liston, Erika Ong, Nathan Ross Bantayan, Sarang Choi, Vikram Sharma, Gurleen Kaur, Fareed Moses M Collado, Annabelle S Volgman, …

Circulation (New York, N.Y.), Vol.148(Suppl_1)

11/07/2023

DOI: 10.1161/circ.148.suppl_1.14815

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Abstract

Abstract only Introduction: Studies have shown higher in-hospital mortality and complications among women who underwent transcatheter aortic valve replacement (TAVR) compared to men. However, most of these studies excluded patients with bicuspid aortic stenosis (BAS). Our aim is to determine if there are sex differences in outcomes among patients with bicuspid AS who underwent TAVR. Methods: This analysis was performed using the National Inpatient Sample (NIS) database. Multivariable regression analyses were performed to adjust for anticipated confounders for in-hospital outcomes. The main multivariable model (model A) included variables on patient demographics and comorbidities. Model B further adjusted for history of myocardial infarction (MI), prior percutaneous coronary intervention (PCI), and prior coronary artery bypass grafting (CABG). The main outcome is in-hospital mortality. ( See figure 1B) Results: More TAVR were performed in men (61.1%) than women (38.9%). Men were more likely to have coronary artery disease, carotid artery disease, and peripheral vascular disease. (See table 1) There was no difference in in-hospital mortality between sexes (1.5 versus 2.4, adjusted odds ratio (aOR) 1.521, 95% confidence interval (CI) 0.523 - 4.424; p< 0.44. Furthermore, there was no sex difference in secondary outcomes. Conclusions: A significantly higher proportion of men undergo the procedure as compared to women. There was no sex difference in in-hospital mortality and other secondary outcomes. More research is needed to address this sex gap in the performance of TAVR in BAS.

TAVI/TAVR

Sex differences

Outcomes

Aortic stenosis

Details

Title: Subtitle: Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample
Creators: Frederick B Rivera - Lincoln Med Cntr, New York, NY
Sonny Redula - Velez College
Mara Bernadette Liston - Velez College
Erika Ong - University of the Philippines Manila
Nathan Ross Bantayan - University of the Philippines Manila
Sarang Choi - Ateneo de Manila University
Vikram Sharma - University of Iowa
Gurleen Kaur - Brigham and Women's Hospital
Fareed Moses M Collado - Rush University
Annabelle S Volgman - Rush University
Mamas Mamas - Univ of Keele, Keele
Resource Type: Abstract
Publication Details: Circulation (New York, N.Y.), Vol.148(Suppl_1)
Publisher: LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
DOI: 10.1161/circ.148.suppl_1.14815
ISSN: 0009-7322
eISSN: 1524-4539
Language: English
Date published: 11/07/2023
Academic Unit: Internal Medicine
Record Identifier: 9984808210602771

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