Abstract
Abstract 15041: Aortic Stiffness is Associated With a Reduced Coronary Flow Reserve
Circulation (New York, N.Y.), Vol.140(Suppl_1), pp.A15041-A15041
11/19/2019
DOI: 10.1161/circ.140.suppl_1.15041
Abstract
IntroductionLarge artery stiffness promotes a steep diastolic pressure decay and an early arrival of wave reflections to the proximal aorta, reducing diastolic pressure augmentation by the reflected wave.MethodsWe assessed the relationship between coronary flow reserve and carotid-femoral pulse wave velocity (CF-PWV) among 101 patients referred for a clinically indicated regadenoson stress cardiac MRI study. We measured CF-PWV using high-fidelity applanation tonometry. Coronary blood flow was assessed semiquantitatively before and after the administration of 5 ml of intravenous regadenoson. Subjects were stratified by tertiles of CF-PWV.ResultsMyocardial perfusion reserve decreased progressively with increasing CF-PWV (ANOVA P=0.0081). MPR was 1.36. 1.22 and 1.08 among subjects with low, intermediate and high PWV, respectively (Figure, left panel). These differences persisted after adjustment for age, sex, race, body mass index, systolic blood pressure, ACE inhibitor or ARB use, long-acting nitrates, hydralazine use and history of diabetes mellitus (ANCOVA P=0.045) (Figure, right panel).ConclusionsConsistent with its important hemodynamic effect on coronary perfusion pressure, our study demonstrated that increased large artery stiffness is associated with a reduced myocardial perfusion reserve.
Details
- Title: Subtitle
- Abstract 15041: Aortic Stiffness is Associated With a Reduced Coronary Flow Reserve
- Creators
- Jonathan Lee - University of PennsylvaniaRushik Bhuva - Geisinger Wyoming Valley Med. Cen., Canton, OHBilal Ansari - University of PennsylvaniaMary Obeid - University of PennsylvaniaSowjanya Yenigalla - UPMC, Pittsburgh, PAArmghan Ans - University of PennsylvaniaGarrett Oldland - University of PennsylvaniaZeba Hashmath - Saint Vincent Hosp, Worcester, MAAnila Hussain - University of PennsylvaniaGurpreet Singh - University of PennsylvaniaQasim Jehangir - University of PennsylvaniaVaibhav Satija - Saint Vincent Hosp, Worcester, MAWalter Witschey - Univesity of Pennsylvania, Philadelphia, PASujith Kuruvilla - University of PennsylvaniaScott Akers - Philadelphia VA Med Cntr, Philadelphia, PAJulio Chirinos - University of Pennsylvania
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.140(Suppl_1), pp.A15041-A15041
- DOI
- 10.1161/circ.140.suppl_1.15041
- ISSN
- 0009-7322
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- Language
- English
- Date published
- 11/19/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985222830102771
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