Abstract
Abstract 15252: Impact of Atrial Fibrillation on Patients With Carcinoid Syndrome: A National In-Patient Sample Analysis
Circulation (New York, N.Y.), Vol.146(S_1), p.A15252
11/08/2022
DOI: 10.1161/circ.146.suppl_1.15252
Abstract
Byline: Akhilesh Babbili, Internal Medicine, LSU-Shreveport, Shreveport, LA; Sahith Reddy Thotamgari, Shreveport, LA; Udhayvir Grewal, Internal Medicine, LSU Health, Shreveport, LA; Anuj Thakre, LSUHSC Shreveport, Shreveport, LA; Paari Dominic, LSUHSC Shreveport, Shreveport, LA Introduction: Carcinoid heart disease is one of the major causes of mortality in patients with carcinoid syndrome. Although right-sided valvular dysfunction is well studied in carcinoid heart, there are limited data on the impact of atrial fibrillation (AF) on in-hospital mortality in these patients. We sought to assess the in-hospital outcomes in patients with carcinoid syndrome and a concurrent diagnosis of AF. Methods: We analyzed the National Inpatient Sample database from January 2016- December 2018 to identify hospitalizations for Carcinoid syndrome using the ICD 10 CM code E34.0. Study cohort was further divided into patients with and without AF. Chi-square test and multivariate logistic regression were used to analyze the association. All statistical analyses were performed using weighted values. Results: During the study period, 9320 hospitalizations with carcinoid syndrome were identified. Among these, 1430 (15.3%) had atrial fibrillation. Baseline characteristics and outcomes are shown in table 1. Patients with AF were older (71.8Ø9.8 vs 63.4Ø13.6, p<0.001) and had a higher Elixhauser comorbidity index (21.5Ø6.6 vs 17.6Ø6.5, p<0.001). AF is noted to be associated with significantly higher in-hospital mortality (OR 2.0, 95% CI 1.6-2.5, p<0.001), and respiratory failure requiring mechanical ventilation (OR 1.9, 95% CI 1.5-2.5, p<0.001). After adjusting for age, sex, race, and significant baseline comorbidities, AF was independently associated with higher in-hospital mortality (aOR 1.64, 95% CI 1.3-2.1, p<0.001*) and mechanical ventilation (aOR 1.88, 95% CI, 1.4-2.5, p<0.001*) Conclusions: Atrial fibrillation is associated with significantly higher in-patient hospital mortality and mechanical ventilation in patients with carcinoid syndrome. Further longitudinal observational studies are needed to validate these findings.
Details
- Title: Subtitle
- Abstract 15252: Impact of Atrial Fibrillation on Patients With Carcinoid Syndrome: A National In-Patient Sample Analysis
- Creators
- Akhilesh BabbiliSahith Reddy ThotamgariUdhayvir GrewalAnuj ThakrePaari Dominic
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.146(S_1), p.A15252
- Publisher
- Lippincott Williams & Wilkins, WK Health
- DOI
- 10.1161/circ.146.suppl_1.15252
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/08/2022
- Description audience
- Professional
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984367152702771
Metrics
4 Record Views