Abstract
Abstract 15459: Left Atrial Enlargement and Ischemic Stroke: A Systematic Review and Meta-Analysis
Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A15459-A15459
11/06/2018
Abstract
Introduction
The relationship between left atrial enlargement (LAE) and ischemic stroke is not well understood. Herein, we conducted a systematic review and meta-analysis to explore the association between LAE and ischemic stroke.
Hypothesis
1) LAE is associated with the first as well as the recurrent ischemic stroke. 2) In ischemic stroke population, LAE is associated with cardioembolic or cryptogenic subtypes.
Method
We comprehensively searched the databases of MEDLINE and EMBASE for articles published until May 2018. The inclusion criterion was observational studies which explore the association between the first or recurrent ischemic stroke and patients with LAE versus normal left atrium. Additionally, the observational studies which demonstrated the relationship between LAE and stroke subtypes were included. The pool odds ratio (OR), hazard ratio (HR), and their 95% confidence interval (CI) were calculated using a random-effects meta-analysis. The between-study heterogeneity of the effect-size was quantified using the Q statistic and the I2.
Results
Twelve studies were included in the analysis. There was a significant association between LAE and the first ischemic stroke in both males and females (Pool OR=1.86; 95%CI1.42-2.44, Male OR=2.11; 95%CI1.34-3.33, and Female OR=1.62; 95%CI1.09-2.40). Compared to other subtypes, LAE was significantly associated with cardioembolic or cryptogenic stroke (OR=3.628; 95%CI 2.44-5.40). Although LAE did not significantly increase the risk of all recurrent strokes (HR=1.63; 95%CI 0.66-4.00), subgroup analysis revealed an increased risk of recurrent cardioembolic or cryptogenic stroke (HR=2.17; 95%CI 1.21-3.90).
Conclusion
LAE is associated with the first ischemic stroke in both genders, especially the cardioembolic or cryptogenic subtypes. Importantly, the risk of recurrent cardioembolic or cryptogenic stroke is significantly increased in patients with LAE.
Details
- Title: Subtitle
- Abstract 15459: Left Atrial Enlargement and Ischemic Stroke: A Systematic Review and Meta-Analysis
- Creators
- Pavida Pachariyanon - Internal Medicine, Texas Tech Health Sciences Cntr, Lubbock, TXSmathorn Thakolwiboon - Neurology, Texas Tech Health Sciences Cntr, Lubbock, TXAmr Ismail - Internal Medicine, Texas Tech Health Sciences Cntr, Lubbock, TXWalter Duarte Celada - Neurology, Texas Tech Health Sciences Cntr, Lubbock, TXWasawat Vutthikraivit - Internal Medicine, Texas Tech Health Sciences Cntr, Lubbock, TXSikarin Upala - University of Chicago
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A15459-A15459
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/06/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695814502771
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