Abstract
Abstract 16238: Pregnancy-Related Events Associated With Subclinical Cardiovascular Disease Burden in Late Midlife: SWAN
Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A16238-A16238
11/06/2018
Abstract
Background and AimReproductive factors (e.g., age at menarche, age at first birth, preeclampsia, gestational diabetes) have been associated with later life cardiovascular disease (CVD) in women, but studies have focused largely on premenopausal women. The purpose of this analysis was to examine the relationship of reproductive factors with a composite index of subclinical CVD burden in late midlife women.MethodsWe included 964 parous women from the Study of Women’s Health Across the Nation (SWAN) who completed a reproductive history questionnaire at the 13th SWAN visit (2011-2012), and a carotid ultrasound assessment and brachial-ankle pulse wave velocity (baPWV) at visit 12 or 13. The primary outcome was a composite subclinical CVD index created using measures of carotid intima-media thickness, plaque, and baPWV. Associations were tested in multinomial logistic regression models adjusting for socio-demographics (i.e., age, race/ethnicity, study site, education, financial strain) and CVD risk factors. Linear regression was performed to examine associations with constituent measures of the composite index.ResultsWomen were on average age 60 years and 94% were postmenopausal. There were 462 (48%) women with a low subclinical CVD index (≤75th percentile for all three subclinical measures), 330 (34%) with a medium subclinical CVD index (>75th percentile for one measure), and 172 (18%) with a high subclinical CVD index (>75th percentile for two to three measures). Reported history of gestational hypertension/preeclampsia was associated with a high subclinical CVD index (OR [95% CI]2.08 [1.12, 3.86]). Earlier age at first birth was associated with a high subclinical CVD index, but not when accounting for CVD risk factors. Reported history of gestational diabetes was not related to our composite index, but was associated with greater baPWV. Age at menarche was not significantly associated with the subclinical CVD index.ConclusionsFindings suggest that pregnancy history is an important marker of subclinical CVD in late midlife. Future studies are necessary to evaluate racial/ethnic differences in the observed associations and to assess the benefit of a composite subclinical CVD index for earlier CVD risk modification in midlife women.
Details
- Title: Subtitle
- Abstract 16238: Pregnancy-Related Events Associated With Subclinical Cardiovascular Disease Burden in Late Midlife: SWAN
- Creators
- Yamnia Cortes - University of North Carolina at Chapel HillMaria Brooks - University of PittsburghJanet Catov - University of PittsburghSamar El Khoudary - University of PittsburghRebecca Thurston - University of PittsburghKaren Matthews - University of PittsburghCarmen Isasi - Albert Einstein College of MedicineElizabeth Jackson - University of Alabama at BirminghamEmma Barinas-Mitchell - University of Pittsburgh
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A16238-A16238
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/06/2018
- Academic Unit
- Nursing
- Record Identifier
- 9984446691302771
Metrics
1 Record Views