Abstract
Abstract 18689: Lower Carotid Artery Compliance and Greater Carotid β-stiffness Index are Associated With Slower Processing Speed and Reduced Working Memory Performance in Older Healthy Adults
Circulation (New York, N.Y.), Vol.132(Suppl_3 ), pp.A18689-A18689
11/10/2015
DOI: 10.1161/circ.132.suppl_3.18689
Abstract
IntroductionHigher central elastic artery stiffness is associated with greater brain white matter hyperintensity volume and lower cognitive performance in older adults. However, it is unknown if higher central artery stiffness is related to regional decreases in brain white matter integrity (WMI) and reductions in working memory or processing speed. We hypothesized that greater large elastic artery stiffness would be associated with lower working memory and slower processing speed as well as lower regional WMI in older adults.MethodsIn young (n=19; 23.8 ± 0.7 yrs) and older (n=22; 64.4 ± 4.2 yrs; range 60-71 yrs) healthy adults, aortic stiffness (carotid-femoral pulse wave velocity, cfPWV, via tonometry) and carotid artery compliance and β-stiffness index (carotid artery ultrasound and tonometry) were determined non-invasively. WMI was assessed by fractional anisotrophy (FA) (3T MRI) from diffusion tensor images. An N-Back task and letter and pattern comparison tests were performed as measures of working memory and processing speed, respectively. d’Prime, a measure of signal detection, was calculated on the N-Back task as a ratio of positive ‘hits’ to ‘false alarm’ responses.ResultscfPWV (8.4 ± 0.5 vs. 5.2 ± 0.2 m/sec, P<0.01) and carotid β-stiffness (11.3 ± 0.9 vs. 6.1 ± 0.7 U, P<0.01) were greater and carotid compliance (0.16 ± 0.02 vs. 0.07 ± 0.01 mm/mmHg, P<0.01) was lower in older vs. young adults. Carotid β, but not aortic, stiffness was associated with slower processing speed on letter (10.7 ± 0.5 vs. 13.5 ± 0.6 units/ 30 sec, p<0.01) and pattern (16.6 ± 0.6 vs. 22.0 ± 0.7 units/30 sec, p<0.01) comparison tasks and reduced working memory (1.8 ± 0.2 vs. 3.1± 0.2, P<0.01) in older vs. young adults. Lower carotid compliance was associated with slower performance on the letter (r=0.55, P<0.01) and pattern (r=0.54, P<0.01) tests and lower d’Prime (r=0.48, P<0.05). Greater β-stiffness was related to pattern comparison scores only (r=-0.54, P<0.01). Aortic stiffness, carotid compliance and β-stiffness were not related to WMI in any brain region.ConclusionsOur results suggest that lower carotid artery compliance and greater β-stiffness are associated with reduced working memory performance and slower processing speed but not regional WMI in older adults.
Details
- Title: Subtitle
- Abstract 18689: Lower Carotid Artery Compliance and Greater Carotid β-stiffness Index are Associated With Slower Processing Speed and Reduced Working Memory Performance in Older Healthy Adults
- Creators
- Lyndsey DuBose - 1Health and Human Physiology, Univ of Iowa, Iowa City, IA 2Dept of Psychology; Aging, Mind and Brain Initiative, Univ of Iowa, Iowa City, IA 3Dept of Psychology, Univ of Iowa, Iowa City, IA 4Internal Medicine; Univ of Iowa Hosp and Clinics, Univ of Iowa, Iowa City, IAMichelle VossTimothy WengKaitlyn DubisharAbbi Lane-CordovaGardar SigurdssonPhillip SchmidGary L Pierce
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.132(Suppl_3 ), pp.A18689-A18689
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- DOI
- 10.1161/circ.132.suppl_3.18689
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/10/2015
- Academic Unit
- Health and Human Physiology; Psychological and Brain Sciences; Internal Medicine; Iowa Neuroscience Institute
- Record Identifier
- 9984071761502771
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