Abstract
Abstract 3852: Obesity is associated with clinical characteristics in African American multiple myeloma patients
Cancer research (Chicago, Ill.), Vol.74(19_Supplement), pp.3852-3852
10/01/2014
DOI: 10.1158/1538-7445.AM2014-3852
Abstract
Abstract
African-American ethnicity, male sex, older age and obesity are accepted risk factors for multiple myeloma (MM). Obesity early in life is a risk factor for many cancers, including MM; most studies have focused on populations of European origin. African-Americans have a higher prevalence of obesity than other populations, and may have a distinct genetic contribution to this condition. We established a multi-center study to investigate possible explanations for the excess risk of MM among African-Americans. The aim of the present case-case analysis was to determine whether body mass index (BMI) was associated with clinical characteristics at presentation in African-American MM patients.
1,065 patients diagnosed with active MM from January 1, 2009 through September 30, 2013 were recruited through nine outpatient centers at academic medical centers and 3 SEER population-based cancer registries. Information on weight and height at 20 years of age and at 5 years prior to diagnosis was obtained from questionnaires. Clinical information collected from the medical records and interviews included age at diagnosis, stage, percent plasmacytosis on bone marrow biopsy,
B2 microglobulin level, immunoglobulin class and presence of lytic bone lesions. Molecular profiling abstracted from pathology reports included chromosomal gain/deletions (1P-, 1Q+, +3, +5, +7, +9, +11, 12P-, Del(13), +15, Del(17P), Del(17P13)), translocations (4;14), (11;14), and (14;16 ). Analysis of Variance (ANOVA) was used to test the null hypothesis that age at diagnosis was similar across BMI categories. A T-test was used to test the null hypothesis that the mean age at diagnosis in underweight/normal patients was not different than that for overweight and obese patients. The Mantel-Haenszel Chi square test for trend was used to test the null hypothesis that the proportion of cytogenetic and molecular abnormalities was similar across BMI categories.
The study population consists of 306 African American male and 396 African American female MM patients. In both, obesity at 20 years of age was associated with younger age at diagnosis, compared to a normal/underweight (p=0.0015). Among males only, obesity at 5 years prior to diagnosis was also associated with younger age at diagnosis (p=0.03). A trend between increasing BMI and molecular characteristics associated with a poor prognosis was suggested.
We observed a strong association between obesity at age 20 and younger age at diagnosis among males and females, and in males only at 5 years prior to diagnosis. Obesity is one of the few known potentially modifiable risk factors for MM. Younger age at diagnosis reflects an earlier accumulation of either or both genetic and environmental risk factors. We also observed a link between obesity at each of the two time points and specific molecular markers of poor prognosis. Additional studies are needed to determine biological significance of the results.
Citation Format: Amie E. Hwang, Sikander Ailwadhi, Carol Ann Huff, Leon Bernal-Mizrachi, Christopher A. Haiman, Edward Peters, Seema Singhal, Karen Pawlish, Cathryn Bock, Todd Zimmerman, David J. Van Den Berg, David V. Conti, Brenda B. Birmann, Jayesh Mehta, John J. Graff, Daniel O. Stram, Niquelle Brown, Yang Yu, Moosa Azadian, Laurence Kolonel, Brian E. Henderson, Ann Mohrbacher, Graham Colditz, Brian-C Chiu, Michael Tomasson, Jeffrey Zonder, Robert Z. Orlowski, Sagar Lonial, Wendy Cozen. Obesity is associated with clinical characteristics in African American multiple myeloma patients. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3852. doi:10.1158/1538-7445.AM2014-3852
Details
- Title: Subtitle
- Abstract 3852: Obesity is associated with clinical characteristics in African American multiple myeloma patients
- Creators
- Amie E. Hwang - USC Norris Comprehensive Cancer CenterSikander Ailwadhi - USC Norris Comprehensive Cancer CenterCarol Ann Huff - University of BaltimoreLeon Bernal-Mizrachi - Emory UniversityChristopher A. Haiman - USC Norris Comprehensive Cancer CenterEdward Peters - Louisiana State UniversitySeema Singhal - University of ChicagoKaren Pawlish - New Jersey Department of HealthCathryn Bock - Wayne State UniversityTodd Zimmerman - University of ChicagoDavid J Van Den BergDavid V. Conti - USC Norris Comprehensive Cancer CenterBrenda B. BirmannJayesh Mehta - University of ChicagoJohn J. Graff - New Jersey Institute of TechnologyDaniel O. Stram - USC Norris Comprehensive Cancer CenterNiquelle Brown - USC Norris Comprehensive Cancer CenterYang Yu - USC Norris Comprehensive Cancer CenterMoosa Azadian - USC Norris Comprehensive Cancer CenterLaurence Kolonel - University of Hawaii SystemBrian E. Henderson - USC Norris Comprehensive Cancer CenterAnn Mohrbacher - USC Norris Comprehensive Cancer CenterGraham Colditz - Washington University in St. LouisBrian-C Chiu - University of ChicagoMichael Tomasson - Washington University in St. LouisJeffrey Zonder - Wayne State UniversityRobert Z. Orlowski - The University of Texas MD Anderson Cancer CenterSagar Lonial - Emory UniversityWendy Cozen - USC Norris Comprehensive Cancer Center
- Resource Type
- Abstract
- Publication Details
- Cancer research (Chicago, Ill.), Vol.74(19_Supplement), pp.3852-3852
- DOI
- 10.1158/1538-7445.AM2014-3852
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Language
- English
- Date published
- 10/01/2014
- Academic Unit
- Health and Human Physiology; Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984363548202771
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