Abstract #4: Global vs. Regional Spinal Cord Atrophy in Multiple Sclerosis

Ashish Arora; Mohit Neema; Shahamat Tauhid; Daniel Goldberg-Zimring; Brian C. Healy; James M. Stankiewicz; Christian Chavarro-Nieto; Antonia Ceccarelli; Elisa Dell'Oglio; Charles R.G. Guttmann; Rohit Bakshi

doi:10.1016/j.nurt.2010.06.006

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Abstract #4: Global vs. Regional Spinal Cord Atrophy in Multiple Sclerosis

Ashish Arora, Mohit Neema, Shahamat Tauhid, Daniel Goldberg-Zimring, Brian C. Healy, James M. Stankiewicz, Christian Chavarro-Nieto, Antonia Ceccarelli, Elisa Dell'Oglio, Charles R.G. Guttmann, …

Neurotherapeutics, Vol.7(3), pp.329-329

07/2010

DOI: 10.1016/j.nurt.2010.06.006

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Abstract

To assess whole and regional spinal cord atrophy in patients with multiple sclerosis (MS) using 3T MRI. Spinal cord damage is common in MS and provides a unique and clinically relevant means to monitor disease progression and therapeutic effects. Whereas regional spinal cord atrophy has been studied extensively in MS, whole spinal cord atrophy has not been previously assessed. Whole spinal cord 3 mm thick T2-weighted axial fast spin-echo MRI images were obtained at 3T on 34 patients with MS [26 women and 8 men; 26 relapsing–remitting, 2 clinically isolated syndrome, 4 secondary progressive, 2 primary progressive; Expanded Disability Status Scale (EDSS) (mean ± SD) 1.95 ± 1.72, range 0–6.5] and 15 age-matched normal controls [11 women and 4 men]. The global and regional (cervical, C2–3, and thoracic) cord volumes were determined using a semi-automated tool and were normalized by the segment length and intracranial volume. Spinal cord lesions were also determined using a semi-automated edge finding tool. Whole cord, C2–3, cervical, and thoracic volumes were lower in progressive vs. relapsing patients or normal controls (all p < 0.05). Spinal cord volumes were not related to spinal cord lesion load but were related to EDSS scores ( r = −0.35 to −0.46; p < 0.05). Only the C2–3 volume correlated with timed 25-foot walk ( r = −0.40; p < 0.05). Whole cord, cervical, C2–3, and thoracic volumes were all highly inter-correlated ( r = 0.83–0.98; p < 0.05). The established method of estimating spinal cord atrophy, C2–3 cross-sectional volume, provides a useful surrogate of overall global or regional spinal cord atrophy. Spinal cord atrophy is most common in progressive forms of MS and is related to neurologic disability. This study was supported by grants from the National Institutes of Health ( 1R01NS055083-01) and the National Multiple Sclerosis Society ( RG3705A1; RG3798A2).

Details

Title: Subtitle: Abstract #4: Global vs. Regional Spinal Cord Atrophy in Multiple Sclerosis
Creators: Ashish Arora - Brigham and Women's Hospital
Mohit Neema - Brigham and Women's Hospital
Shahamat Tauhid - Brigham and Women's Hospital
Daniel Goldberg-Zimring - Brigham and Women's Hospital
Brian C. Healy - Brigham and Women's Hospital
James M. Stankiewicz - Brigham and Women's Hospital
Christian Chavarro-Nieto - Brigham and Women's Hospital
Antonia Ceccarelli - Brigham and Women's Hospital
Elisa Dell'Oglio - Brigham and Women's Hospital
Charles R.G. Guttmann - Brigham and Women's Hospital
Rohit Bakshi - Brigham and Women's Hospital
Resource Type: Abstract
Publication Details: Neurotherapeutics, Vol.7(3), pp.329-329
DOI: 10.1016/j.nurt.2010.06.006
ISSN: 1933-7213
eISSN: 1878-7479
Publisher: Elsevier Inc
Grant note: 1R01NS055083-01 / National Institutes of Health RG3705A1; RG3798A2 / National Multiple Sclerosis Society
Language: English
Date published: 07/2010
Academic Unit: Psychiatry
Record Identifier: 9984631941102771

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