Abstract
Abstract 4140767: MRI-Measured Myocardial Strain as a Predictor of Clinical Outcomes in Systemic RV
Circulation (New York, N.Y.), Vol.150(Suppl_1), pp.A4140767-A4140767
11/12/2024
DOI: 10.1161/circ.150.suppl_1.4140767
Abstract
Background: Systemic RV dysfunction is a common concern in patients with d-Transposition of the great arteries (d-TGA) after atrial switch and congenitally corrected TGA (ccTGA). We investigated myocardial strain on MRI to predict clinical outcomes.
Methods: We analyzed 50 MRI studies (33 d-TGA with atrial switch, 17 ccTGA, mean age 42 ± 13 years) after excluding studies with fewer than 30 phases or incomplete images. Feature-tracking of SSFP cine was retrospectively utilized to quantify radial, circumferential, and longitudinal strain in both 2 and 3 dimensions. Physiological class (PC) was determined by clinicians according to the 2018 AHA/ACC guidelines. Clinical events (e.g., change in PC, initiation or escalation of diuretics, mortality, arrhythmias, heart failure hospitalization) over a 5-year period were obtained through chart review.
Results: Deterioration of PC was significantly associated with worsening of all strain measures (p ≤0.05 for each) except 3D global radial strain. RV ejection fraction (EF) was also significant (p ≤0.05). Importantly, in patients experiencing new clinical events within 5 years, baseline absolute values of global longitudinal strain (2D and 3D) were significantly worse (p ≤0.05 for both), whereas RVEF was not (Figure).
Conclusion: MRI-measured global longitudinal strain holds promise as a prognostic indicator for clinical outcomes in adults with systemic RV dysfunction. These findings underscore its potential utility in risk stratification and guiding management decisions.
Details
- Title: Subtitle
- Abstract 4140767: MRI-Measured Myocardial Strain as a Predictor of Clinical Outcomes in Systemic RV
- Creators
- Hidemi Kajimoto - Oregon Health and Science University HospitalCraig Broberg - Oregon Health and Science University Hospital
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.150(Suppl_1), pp.A4140767-A4140767
- DOI
- 10.1161/circ.150.suppl_1.4140767
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- Lippincott Williams & Wilkins; PHILADELPHIA
- Language
- English
- Date published
- 11/12/2024
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961020402771
Metrics
1 Record Views