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Abstract 4145439: Cardiac Arrest Associated with Thyrotoxicosis: A Systematic Review
Abstract   Peer reviewed

Abstract 4145439: Cardiac Arrest Associated with Thyrotoxicosis: A Systematic Review

Ashraf Ahmed, Mohamed Badheeb, Shaun Abid, Fabricio Malaguez Webber, Samdish Sethi, Mayowa Adefuye, Deepak Vangipuram, Anda Gonciulea, Stuart Zarich and Gregory Buller
Circulation (New York, N.Y.), Vol.150(Suppl_1), pp.A4145439-A4145439
11/12/2024
DOI: 10.1161/circ.150.suppl_1.4145439

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Abstract

Introduction: Thyrotoxicosis is a systemic condition caused by the effects of elevated levels of thyroid hormones. The cardiovascular manifestations of thyrotoxicosis range from sinus tachycardia and atrial fibrillation to heart failure. The incidence of malignant arrhythmias and cardiac arrest associated with thyrotoxicosis is not well known, and much of the current literature regarding this is limited to case reports. This study conducts a systematic review of the literature to identify patient demographics and outcomes where thyrotoxicosis manifests as cardiac arrest. Methodology: A systematic literature review was conducted by searching three different databases, Embase, PubMed, and Scopus from inception to January 5th, 2024, to identify and review case reports regarding patients with thyrotoxicosis who had a cardiac arrest. Results: We identified 98 patients with thyrotoxicosis manifested as cardiac arrest. The mean age was 40 ±15 years, and 62% were female. Most were previously healthy and had no history of a thyroid disorder (60%). Of the patients with preexisting hyperthyroidism, around 50% had Graves' disease. Notably, around 90% of these patients had no history of heart disease. The overall mortality was 23.5% (table 1). Conclusion: Thyrotoxicosis should be considered when an otherwise healthy patient presents with a cardiac arrest in the third or fourth decade of life. The outcome in these patients seems to be favorable, with more than three-quarters of patients in our study having survived the event.
 Sudden cardiac death Arrhythmias Thyroid hormones

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