Abstract
Abstract 43: Circulating Omega-3 Fatty Acid Levels and Total and Cause-specific Mortality: Prospective Evidence From 14 Cohorts in the Fatty Acids and Outcomes Research Consortium
Circulation (New York, N.Y.), Vol.141(Suppl_1)
03/03/2020
DOI: 10.1161/circ.141.suppl_1.43
Abstract
Background:
Several recent studies have linked higher blood levels of the long-chain omega-3 polyunsaturated fatty acids (PUFAs) with lower risk of certain disease outcomes, in particular cardiovascular disease (CVD). Limited studies have evaluated associations between n-3 PUFA levels and total and cause-specific mortality.
Methods:
We meta-analyzed the association of circulating omega-3 PUFAs with total and cause-specific mortality from 15 distinct cohorts in 10 countries following a total of 36,840 individuals (baseline average age 66 yrs; 47% female; median follow-up 13.7 yrs), with 11,635 deaths. Total mortality, and 3 cause-specific mortalities (CVD, cancer or other), were separately predicted by levels of the long chain omega-3 PUFAs eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA) and the Omega-3 index (EPA+DHA), as well as levels of alpha-linolenic acid (ALA, an intermediate chain n-3 PUFA). Using cohort-specific fatty acid levels (range from 10
th
to 90
th
percentiles), each cohort fit a Cox regression model adjusting for demographics, health related covariates, and n-6 PUFA levels. Cohort-specific estimates were pooled with inverse-variance weighted meta-analysis.
Results:
Higher levels of EPA, DPA, DHA and the Omega-3 index were all associated with lower all-cause mortality [EPA meta-analysis Hazard Ratio (HR)=0.90 (95% CI: 0.85, 0.95), DPA HR=0.84 (95% CI: 0.77, 0.91), DHA HR=0.84 (95% CI: 0.75, 0.93), Omega-3 index HR = 0.84 (95% CI 0.77, 0.92) (Figure)], as well as for each cause-specific mortality (CVD, cancer and other; HRs from 0.85 to 0.92). ALA showed no association with total-mortality or cause-specific mortality [HRs from 0.97 to 1.00)].
Conclusions:
We have found strong evidence of inverse associations between long-chain omega-3 PUFA levels and all-cause and cause-specific mortality. Further controlled studies are needed in order to determine the extent to which these observations represent a causal or coincidental relationships.
Details
- Title: Subtitle
- Abstract 43: Circulating Omega-3 Fatty Acid Levels and Total and Cause-specific Mortality: Prospective Evidence From 14 Cohorts in the Fatty Acids and Outcomes Research Consortium
- Creators
- Nathan Tintle - Dordt UniversityJulie Bassett - Cancer Council VictoriaKuo-Liong Chien - National Taiwan UniversityNita Forouhi - University of CambridgeLeanne Kupers - Wageningen University & ResearchMaria Lankinen - University of Eastern FinlandRozenn Lemaitre - University of WashingtonJoan Lindsay - University of OttawaMatti Marklund - George Institute for Global HealthRachel Murphy - University of British ColumbiaToshiharu Ninomiya - Kyushu UniversityJennifer G Robinson - University of IowaCecilia Samieri - Bordeaux Population HealthDavid Siscovick - NY Academy of Medicine, New York, NYJyrki K Virtanen - University of Eastern FinlandAlexis Wood - Baylor College of MedicineDariush MozaffarianWilliam S Harris - Omegaquant Analytics, Sioux Falls, SD
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.141(Suppl_1)
- DOI
- 10.1161/circ.141.suppl_1.43
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 03/03/2020
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364535402771
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