Abstract
Abstract 4373171: Progressive Diastolic Dysfunction Detected by Cardiac MRI in Adults with a Systemic Right Ventricle
Circulation (New York, N.Y.), Vol.152(Suppl_3), pp.A4373171-A4373171
11/04/2025
DOI: 10.1161/circ.152.suppl_3.4373171
Abstract
Background: Systemic right ventricular (RV) dysfunction is a major clinical concern in adults with d-transposition of the great arteries (d-TGA) after atrial switch and those with congenitally corrected TGA (ccTGA). While systolic dysfunction has been well characterized, diastolic dysfunction remains poorly understood in this population. Diastolic strain rate, a marker of early myocardial relaxation, may offer insights into subclinical diastolic impairment. We aimed to characterize longitudinal changes in myocardial diastolic strain using cardiac magnetic resonance imaging (MRI).
Methods: We retrospectively evaluated baseline and follow-up cardiac MRI studies in 34 adults with a systemic RV (26 with d-TGA post-atrial switch, 8 with ccTGA). The median follow-up interval was 4 years (range: 1-10 years). Global diastolic strain rates (1/s) were derived from feature tracking of steady-state free precession (SSFP) cine sequences in short- and long-axis views, assessing radial, circumferential, and longitudinal directions.
Results: Both radial and circumferential global diastolic strain rates significantly declined over time (p ≤ 0.05), consistent with progressive diastolic dysfunction. In contrast, longitudinal global diastolic strain rate remained unchanged.
Conclusion: Cardiac MRI-based diastolic strain analysis revealed progressive impairment in radial and circumferential relaxation in adults with a systemic RV, while longitudinal function was preserved. These findings underscore the value of MRI-derived diastolic strain as a potential tool for early detection of dysfunction and longitudinal surveillance in this high-risk population.
Details
- Title: Subtitle
- Abstract 4373171: Progressive Diastolic Dysfunction Detected by Cardiac MRI in Adults with a Systemic Right Ventricle
- Creators
- Hidemi Kajimoto - Oregon Health and Science University HospitalCraig Broberg - Oregon Health and Science University Hospital
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.152(Suppl_3), pp.A4373171-A4373171
- DOI
- 10.1161/circ.152.suppl_3.4373171
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- Lippincott Williams & Wilkins
- Language
- English
- Date published
- 11/04/2025
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9985022568002771
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