Abstract
Abstract 5529: CD177 suppresses breast cancer progression by regulating the canonical WNT β-Catenin pathway
Cancer research (Chicago, Ill.), Vol.77(13_Supplement), pp.5529-5529
07/01/2017
DOI: 10.1158/1538-7445.AM2017-5529
Abstract
Abstract To better treat breast cancer patients, it is imperative to be able to predict breast cancer relapse and metastasis. Here, we identified the cluster of differentiation 177 (CD177) expression is positively correlated with relapse-free and metastasis-free survival of breast cancer patients. CD177 protein is highly expressed in normal breast epithelial cells and is significantly reduced in invasive cancers. Using mouse models, we found that CD177 suppresses breast cancer, primarily by forming a complex with E-Cadherin and b-Catenin at adherens junctions. The physical interaction prevents the activation of b-Catenin-mediated transcription by the canonical WNT signaling as demonstrated by a TOP-flash dual luciferase assay. In conclusion, we have identified CD177 as a novel breast cancer suppressor and uncovered a new regulatory mechanism for the canonical WNT/b-Catenin-mediated oncogenic signaling transduction. Citation Format: Paige N. Kluz, Ryan Kolb, Qing Xie, Nicholas Borcherding, Linna Wang, James P. De Andrade, Phillip M. Spanheimer, Wei Li, Katherine N. Gibson-Corley, Andy W. Tao, Sonia Sugg, Ronald J. Weigel, Weizhou Zhang. CD177 suppresses breast cancer progression by regulating the canonical WNT β-Catenin pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5529. doi:10.1158/1538-7445.AM2017-5529
Details
- Title: Subtitle
- Abstract 5529: CD177 suppresses breast cancer progression by regulating the canonical WNT β-Catenin pathway
- Creators
- Paige N. KluzRyan KolbQing XieNicholas BorcherdingLinna WangJames P. De AndradePhillip M. SpanheimerWei LiKatherine N. Gibson-CorleyAndy W. TaoSonia SuggRonald J. WeigelWeizhou Zhang
- Resource Type
- Abstract
- Publication Details
- Cancer research (Chicago, Ill.), Vol.77(13_Supplement), pp.5529-5529
- DOI
- 10.1158/1538-7445.AM2017-5529
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Language
- English
- Date published
- 07/01/2017
- Academic Unit
- Molecular Physiology and Biophysics; Orthopedics and Rehabilitation; Surgery; The University of Iowa Institute for Vision Research; Dermatology; Anatomy and Cell Biology; Biochemistry and Molecular Biology; Radiation Oncology
- Record Identifier
- 9984288598702771
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