Abstract #7: Voxel Based Morphometry with DARTEL in Multiple Sclerosis

Antonia Ceccarelli; Jonathan S. Jackson; Ashish Arora; Shahamat S. Tauhid; Christian Chavarro-Nieto; Elisa Dell'Oglio; Daniel Goldberg-Zimring; Anshika Bakshi; Rohit Bakshi; Mohit Neema

doi:10.1016/j.nurt.2010.06.009

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Abstract #7: Voxel Based Morphometry with DARTEL in Multiple Sclerosis

Antonia Ceccarelli, Jonathan S. Jackson, Ashish Arora, Shahamat S. Tauhid, Christian Chavarro-Nieto, Elisa Dell'Oglio, Daniel Goldberg-Zimring, Anshika Bakshi, Rohit Bakshi and Mohit Neema

Neurotherapeutics, Vol.7(3), pp.330-330

07/2010

DOI: 10.1016/j.nurt.2010.06.009

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Abstract

Voxel based morphometry (VBM) is an automated tool used to assess the topography and magnitude of cerebral atrophy from MRI scans. However, VBM output is highly dependent on the input provided by registration and segmentation algorithms. Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) is a new tool which has recently been developed to improve registration in healthy volunteers (HV) and neurodegenerative diseases. This has not yet been applied to multiple sclerosis (MS). To assess regional gray matter (GM) and white matter (WM) atrophy using VBM combined with DARTEL in MS patients. Using a 3T MRI scanner, fluid-attenuated inversion-recovery (FLAIR) and 3D spoiled gradient recalled (SPGR) scans were acquired from 26 relapsing remitting (RR) MS patients [age (mean ± SD) 39.2 ± 9.4 years, disease duration 8.5 ± 5.9 years, Expanded Disability Status Scale (EDSS) score 1.2 ± 0.9, FLAIR lesion volume (FLV) 15.0 ± 14.7 mL] and 28 sex- and age-matched HV. MS lesions on SPGR and FLAIR images were traced using a semi-automated thresholding tool. VBM was performed using DARTEL with statistical parametric mapping (SPM8) software from SPGR images. An analysis of covariance was used to assess differences in GM and WM volume between MS patients and HV. Age, gender, and intracranial volume were included as covariates. Compared with HV, MS patients showed significant GM atrophy in the bilateral thalami, bilateral caudate, and right putamen. Furthermore, WM atrophy was found in the brainstem, corpus callosum, fornix, and bilateral temporal and occipital lobes. FLV significantly correlated with GM atrophy in the thalami and with WM atrophy in the brainstem, temporal lobes, and corpus callosum. VBM-DARTEL reveals widespread WM and GM cerebral atrophy affecting many areas of the brain, which is associated with overt lesions in MS patients. This pilot study suggests that VBM-DARTEL is a promising tool to derive meaningful disease specific information in MS. This work was supported by research grants from the National Institutes of Health ( NIH R01 NS055083-01) and the National Multiple Sclerosis Society ( RG3705A1, RG3798A2).

Details

Title: Subtitle: Abstract #7: Voxel Based Morphometry with DARTEL in Multiple Sclerosis
Creators: Antonia Ceccarelli - Brigham and Women's Hospital
Jonathan S. Jackson - Brigham and Women's Hospital
Ashish Arora - Brigham and Women's Hospital
Shahamat S. Tauhid - Brigham and Women's Hospital
Christian Chavarro-Nieto - Brigham and Women's Hospital
Elisa Dell'Oglio - Brigham and Women's Hospital
Daniel Goldberg-Zimring - Brigham and Women's Hospital
Anshika Bakshi - Brigham and Women's Hospital
Rohit Bakshi - Brigham and Women's Hospital
Mohit Neema - Brigham and Women's Hospital
Resource Type: Abstract
Publication Details: Neurotherapeutics, Vol.7(3), pp.330-330
DOI: 10.1016/j.nurt.2010.06.009
ISSN: 1933-7213
eISSN: 1878-7479
Publisher: Elsevier Inc
Grant note: NIH R01 NS055083-01 / National Institutes of Health RG3705A1; RG3798A2 / National Multiple Sclerosis Society
Language: English
Date published: 07/2010
Academic Unit: Psychiatry
Record Identifier: 9984632141002771

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