Abstract
Abstract 9486: Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults
Circulation (New York, N.Y.), Vol.144(Suppl_1), p.A9486
11/16/2021
DOI: 10.1161/circ.144.suppl_1.9486
Abstract
Background:
The neurocognitive effect of statins in older adults remains uncertain.
Objectives:
To investigate the associations of statin use with cognitive decline and incident dementia among older adults.
Methods:
This analysis included 18,846 participants (aged ≥65 years) from a randomized trial of aspirin (ASPirin in Reducing Events in the Elderly, ASPREE). At baseline, participants had no experience of a CVD event, major physical disability, or diagnosed dementia, and were followed for a median (IQR) of 4.7 (3.5-5.6) years. Outcome measures included incident dementia and its subclassifications (probable Alzheimer’s disease [AD]; mixed presentations), changes in domain-specific cognition (global cognition, memory, language and executive function, psychomotor speed) and the composite of these domains. We examined the associations of baseline statin use with dementia using Cox proportional-hazards models, and with cognitive change using linear mixed-effects models, adjusting for confounders. The role of statin lipophilicity was also examined.
Results:
Compared with no statin, baseline statin use was not associated with incident dementia (adjusted HR [95%CI]: 1.16 [0.97-1.40]), probable AD (1.33 [1.00-1.77]) or mixed presentations of dementia (1.06 [0.82-1.35]) (
Table 1
). Nor was it associated with changes in composite or domain-specific cognitive function scores over time (
Table 2
). No differences were found in any outcomes between hydrophilic and lipophilic statin users (
Tables 1 & 2
).
Conclusions:
In healthy adults aged ≥65 years without diagnosed dementia, statin therapy over 4.7 years was not associated with incident dementia or cognitive decline.
Details
- Title: Subtitle
- Abstract 9486: Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults
- Creators
- Zhen Zhou - University of TasmaniaJoanne Ryan - Monash UniversityMichael E Ernst - University of IowaSophia Zoungas - Monash UniversityAndrew M Tonkin - Monash UniversityRobyn L Woods - Monash UniversityJohn J McNeil - Sch of Public Health and Preventive Medicine, Monash Univ, Melbourne, AustraliaChristopher Reid - Curtin UniversityAndrea J Curtis - Monash UniversityRory Wolfe - Monash UniversityJo Wrigglesworth - Monash UniversityRaj C Shah - Rush UniversityElsdon Storey - Monash UniversityAnne Murray - Berman Cntr for Outcomes and Clinical Rsch, Hennepin HealthCare Rsch Institute, Edina, MNSuzanne G Orchard - Monash UniversityMark R Nelson - University of Tasmania
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.144(Suppl_1), p.A9486
- DOI
- 10.1161/circ.144.suppl_1.9486
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/16/2021
- Academic Unit
- Pharmacy Practice and Science; Family Medicine
- Record Identifier
- 9984297652402771
Metrics
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