Abstract
Abstract B055: Guideline-concordance along the cancer care continuum and breast cancer mortality by race and ethnicity: A SEER-Medicare study
Cancer epidemiology, biomarkers & prevention, Vol.34(9_Supplement), pp.B055-B055
09/18/2025
DOI: 10.1158/1538-7755.DISP25-B055
Abstract
Purpose.
To examine the relationship between guideline-concordant breast cancer care and hazard of cancer death by patient race and ethnicity.
Methods.
We used SEER-Medicare data to identify 212,555 older women diagnosed with invasive breast cancer between 2000-2017. Guideline-concordant diagnostic workup, locoregional treatment, and initiation of systemic therapy were defined using NCCN guidelines. Hazards of breast cancer death 2- and 5-years from diagnosis by each guideline-concordance outcome overall and stratified by race and ethnicity were estimated using Cox proportional hazards models.
Results.
Non-concordant diagnostic workup, locoregional treatment, and systemic therapy initiation were each associated with increased hazards of 2- and 5-year breast cancer mortality (diagnostics HR2-year (95% CI) 1.33 (1.25-1.41), HR5-year 1.29 (1.23-1.35); locoregional HR2-year 2.18 (2.10-2.30), HR5-year 1.85 (1.78-1.92); systemics HR2-year 1.62 (1.50-1.80), HR5-year 1.51 (1.42-1.62)). Non-concordant diagnostic workup and systemic therapy initiation were associated with greater hazard of 2- and 5-year breast cancer death among Black, Asian/Pacific Islander, Hispanic White, and non-Hispanic White patients; there was no consistent association among American Indian/Alaska Native patients for either outcome. Locoregional treatment was strongly associated with hazards of cancer death for all groups.
Conclusions.
Equitable delivery of guideline-recommended breast cancer care from diagnosis through treatment across racial and ethnic groups may mitigate survival disparities. Efforts to improve access to high-quality care must be informed by and responsive to the social and structural root causes of health inequities
Details
- Title: Subtitle
- Abstract B055: Guideline-concordance along the cancer care continuum and breast cancer mortality by race and ethnicity: A SEER-Medicare study
- Creators
- Emma L. Herbach - Sylvester Comprehensive Cancer CenterRyan M. Carnahan - University of IowaLauren E. McCullough - Emory UniversityBradley D. McDowell - University of IowaMichaela Curran - University of IowaKai Wang - University of IowaIngrid M. Lizarraga - University of IowaMary E. Charlton - University of IowaSarah H. Nash - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.34(9_Supplement), pp.B055-B055
- DOI
- 10.1158/1538-7755.DISP25-B055
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Publisher
- AMER ASSOC CANCER RESEARCH
- Language
- English
- Date published
- 09/18/2025
- Academic Unit
- Epidemiology; Biostatistics; Surgery; Nursing; Injury Prevention Research Center; Community and Behavioral Health; Holden Comprehensive Cancer Center
- Record Identifier
- 9984966339802771
Metrics
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