Abstract
Abstract P160: Long-term Blood Pressure Variability And Cognitive Decline And Dementia Among Community-dwelling Elderly
Hypertension (Dallas, Tex. 1979), Vol.76(Suppl_1)
09/2020
DOI: 10.1161/hyp.76.suppl_1.P160
Abstract
Greater blood pressure variability (BPV) in midlife increases the risk of dementia, but the impact of BPV in cognitively intact older adults is unknown. We examined the risk of incident dementia and cognitive decline associated with long-term, visit-to-visit BPV in participants of the ASPirin in Reducing Events in the Elderly (ASPREE) study, a randomized primary prevention trial of daily low-dose aspirin in community-dwelling adults in Australia and the US aged 70 and older (65 if US minority), who were free of dementia or evidence of cognitive impairment at enrollment. The mean of three BPs using an automated cuff was recorded at baseline and annually; participants also underwent baseline and biennial standardized assessments of global cognition, delayed episodic memory, verbal fluency, processing speed and attention. Cognitive decline was pre-specified as a >1.5 standard deviation (SD) decline in score from baseline on any of the cognitive tests, while incident dementia was a pre-specified secondary endpoint of ASPREE which was adjudicated using DSM-IV criteria. BPV was estimated using within-individual SD of mean systolic BP across baseline and the first two annual visits, and participants with cognitive decline or incident dementia during this period were excluded from the analysis to avoid immortal time bias. After adjustment for key covariates, Cox proportional hazards regression revealed increased risks for dementia and cognitive decline during follow-up for individuals in the highest SD tertile of BPV (Table). Our findings suggest that high BPV in older ages should be considered a potential therapeutic target to preserve cognitive function.
Details
- Title: Subtitle
- Abstract P160: Long-term Blood Pressure Variability And Cognitive Decline And Dementia Among Community-dwelling Elderly
- Creators
- Michael E Ernst - University of IowaJoanne Ryan - Monash UniversityEnayet K Chowdhury - Monash UniversityAnne M Murray - Hennepin Healthcare Research InstituteRobyn L Woods - Monash UniversitySuzanne G Orchard - Monash UniversityRory Wolfe - Monash UniversityElsdon Storey - Monash UniversityRaj C Shah - Rush UniversityAndrew Tonkin - Monash UniversityChristopher M Reid - Curtin University
- Resource Type
- Abstract
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.76(Suppl_1)
- DOI
- 10.1161/hyp.76.suppl_1.P160
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Pharmacy Practice and Science; Family Medicine
- Record Identifier
- 9984297547602771
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