Abstract
Abstract P168: Parity Is Associated With Higher Arterial Stiffness But Not Its 5-year Change In Older Women: The Atherosclerosis Risk In Communities - Neurocognitive Study
Circulation (New York, N.Y.), Vol.143(Suppl_1), p.AP168
05/25/2021
DOI: 10.1161/circ.143.suppl_1.P168
Abstract
Abstract only
Introduction:
Although studies have demonstrated a J-shaped association of parity with cardiovascular disease, the association with vascular disease is not fully understood. We examined the association between parity and carotid-femoral pulse wave velocity (cfPWV), a measure of arterial stiffness.
Hypothesis:
Women who were never pregnant or had no live births and women with 5+ live births would have higher cfPWV and 5-year cfPWV change compared to women with 1-2 live births.
Materials and Methods:
We included 1220 women (average age 73.7; 21.9% Black) from the Atherosclerosis Risk in Communities - Neurocognitive Study, a cohort of 15,792 adults enrolled in 1987-1989 from four communities: Forsyth Co., NC; Jackson, MS; Minneapolis, MN; and Washington Co., MD. Technicians measured cfPWV at visit 5 (2011-13) and visit 6 or 7 (2016-19). At visit 2 (1990-92), women self-reported parity (number of prior live births), which we categorized as never pregnant or pregnant but no live births, 1-2 (referent), 3-4, and 5+ live births. We used linear regression models to evaluate associations of parity with visit 5 cfPWV and 5-year cfPWV change, adjusting for years between visits 5 and 6 or 7, age, race-center, education, body mass index, heart rate, mean arterial pressure, hypertension medication, and diabetes.
Results:
Participants reported having had no (7.7%), 1-2 (38.7%), 3-4 (40.0%), or 5+ (13.6%) prior live births. Women with 5+ live births had a higher visit 5 cfPWV (β=50.6 cm/s, 95% confidence interval (CI): 3.6-97.7 cm/s; Table) as compared to those with 1-2 live births. No statistically significant associations were observed for other parity groups and visit 5 cfPWV or cfPWV change.
Conclusions:
In later life, women with 5+ live births had higher arterial stiffness than those with 1-2 live births, but the rate of cfPWV change did not differ by parity. Longitudinal arterial stiffness measurements at mid-life are needed to better understand the effect of pregnancy on the trajectory of arterial stiffness among women in later life.
Details
- Title: Subtitle
- Abstract P168: Parity Is Associated With Higher Arterial Stiffness But Not Its 5-year Change In Older Women: The Atherosclerosis Risk In Communities - Neurocognitive Study
- Creators
- Alison N Bonner - University of North Carolina at Chapel HillShantal Jayawickreme - University of North Carolina at Chapel HillAngela M Malek - Medical University of South CarolinaCatherine J Vladutiu - University of North Carolina at Chapel HillClare Oliver-Williams - University of CambridgeYamnia I Cortes - University of North Carolina at Chapel HillHirofumi Tanaka - The University of Texas at AustinMichelle L Meyer - University of North Carolina at Chapel Hill
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.143(Suppl_1), p.AP168
- DOI
- 10.1161/circ.143.suppl_1.P168
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 05/25/2021
- Academic Unit
- Nursing
- Record Identifier
- 9984447839102771
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