Abstract
Abstract P169: Change In Blood Pressure Level And Its Association With Cardiovascular Events In The Healthy Elderly: Findings From The Aspirin In Reducing Events In The Elderly Trial
Hypertension (Dallas, Tex. 1979), Vol.76(Suppl_1)
09/2020
DOI: 10.1161/hyp.76.suppl_1.P169
Abstract
Blood pressure (BP) increases with age and is a major risk factor for cardiovascular disease (CVD). We examined change in BP level over a median of 4.7 years in ASPirin in Reducing Events in the Elderly trial participants, and its association with CVD events. Participants with baseline and at least one in-trial BP measurement were included. Since CVD event can affect BP (before and after), participants having a non-fatal CVD event in between in-trial BP records were excluded. Participants were classified according to baseline BP level, irrespective of antihypertensive use, into three groups (A) normal (SBP<130 & DBP<80 mmHg), (B) elevated (SBP 130-139 and/or DBP 80-89) and (C) high (BP≥140/90). Thereafter, based on the average of their in-trial BP level, participants were again classified into three BP categories (i.e. normal /elevated /high). Cox proportional hazards regression was used to examine the association of CVD events with change in BP group in relation to their baseline. 17543 ASPREE participants were included in the analysis. At baseline, 26% had normal, 25% had elevated and 49% had high BP. Participants’ BP status during the trial period and its association with CVD events in relation to baseline BP category are summarized in the Figure. Among those with high BP at baseline, 60% remained with high BP, 28% moved down to elevated BP, and 11% moved to normal BP. Reduced CVD risk was observed among participants who reduced BP to elevated BP category from high BP during the trial period. However, no difference was observed in risk reduction among those achieving normal BP levels from baseline high BP. An increase in BP from normal category demonstrates a two times increase in CVD risk.
Details
- Title: Subtitle
- Abstract P169: Change In Blood Pressure Level And Its Association With Cardiovascular Events In The Healthy Elderly: Findings From The Aspirin In Reducing Events In The Elderly Trial
- Creators
- Enayet K Chowdhury - Curtin UniversityMichael E Ernst - UNIVERSITY IOWA HC, Iowa City, IAMark R Nelson - University of TasmaniaLawrence J Beilin - University of Western AustraliaKaren L Margolis - HealthPartnersRory Wolfe - Monash UniversityAndrew Tonkin - Monash UniversityRobyn Woods - Monash UniversityJohn J McNeil - Monash UniversityChristopher Reid - 1958, SOUTH PERTH ANGELO ST, Australia
- Resource Type
- Abstract
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.76(Suppl_1)
- DOI
- 10.1161/hyp.76.suppl_1.P169
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Pharmacy Practice and Science; Family Medicine
- Record Identifier
- 9984297546202771
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