Abstract P172: Impairment Of Estrogen Protective Effect Contributes To Maternal Gestational Hypertension-induced Sensitization Of Hypertensive Response To Post-weaning High Fat Diet In Female Adult Offspring
Hypertension (Dallas, Tex. 1979), Vol.78(S_1), p.AP172
09/01/2021
: 10.1161/hyp.78.suppl_1.P172
Byline: Baojian Xue, UNIVERSITY OF IOWA, Iowa City, IA; Yang Yu, Univ of Iowa, Iowa City, IA; Terry Beltz, Univ of Iowa, Iowa City, IA; Fang Guo, Unversity of Iowa, Iowa City, IA; Shun-Guang Wei, UNIVERSITY OF IOWA, Iowa City, IA; Jennifer S Pollock, UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL; David M Pollock, Univ of Alabama at Birmingham, Birmingham, AL; Alan K Johnson, UNIVERSITY IOWA, Iowa City, IA Obesity/high fat diet (HFD) is a risk factor for cardiovascular diseases including hypertension. Recent evidence indicates that maternal gestational hypertension (MGHT) induces hypertensive response sensitization (HTRS) elicited by post-weaning HFD in both male and female offspring. However, the increase in blood pressure (BP) in female offspring is less than that in male offspring. In this study, we investigated if estrogen plays a protective role in MGHT-induced HTRS to post-weaning HFD in female offspring, and if estrogen effects are associated with regulation of brain reactivity to pressor agents and altered autonomic function. In post-weaning HFD fed intact female offspring, MGHT induced HFD-elicited HTRS (MAP, offspring of NT dams, 107.9Ø0.9 to 115.2Ø0.7 mmHg; offspring of MGHT dams, 107.3Ø0.8 to 120.7Ø1.4 mmHg, p<0.05) and enhanced pressor responses to centrally administered angiotensin (ANG) II (ðö13.7Ø1.1 mmHg, p<0.05 vs NFD offspring) and tumor necrosis factor ð (TNF-ð) (ðö13.1Ø0.7 mmHg, p<0.05 vs NFD offspring). Ovariectomy (OVX) significantly enhanced the HFD-induced increase in BP (115.2Ø0.7 to 127.1Ø2.2 mmHg, p<0.05) and the pressor response to central ANG II (ðö11.2Ø0.9 to ðö18.7Ø2.3 mmHg, p<0.05) or TNF-ð (ðö10.0Ø1.0 to ðö16.5Ø1.6 mmHg, p<0.05) in HFD offspring of normotensive (NT) dams. However, MGHT-induced HTRS (MAP, 122.5Ø1.9 mmHg) and pressor responses to ANG II (ðö16.3Ø1.0 mmHg) or TNF-ð (ðö14.9Ø1.0 mmHg) in HFD-fed intact offspring of MGHT dams were not potentiated further after OVX when compared to HFD-fed OVX offspring of NT dams. The resting BP and elicited pressor responses remained higher than that of NFD fed offspring of both NT and MGHT dams. Moreover, OVX induced an increase in central nervous system sympathetic drive, and HFD feeding potentiated this effect. The results indicate that estrogen normally plays a protective role in antagonizing HFD prohypertensive effects in offspring of NT dams. MGHT compromises this normal protective action of estrogen to induce HTRS elicited by HFD, which is through augmenting brain reactivity and centrally driven sympathetic activity.
- Abstract P172: Impairment Of Estrogen Protective Effect Contributes To Maternal Gestational Hypertension-induced Sensitization Of Hypertensive Response To Post-weaning High Fat Diet In Female Adult Offspring
- Baojian Xue - University of IowaYang Yu - University of IowaTerry Beltz - University of IowaFang Guo - University of IowaShun-Guang Wei - University of IowaJennifer S Pollock - University of Alabama at BirminghamDavid M Pollock - University of Alabama at Birmingham
- Abstract
- Hypertension (Dallas, Tex. 1979), Vol.78(S_1), p.AP172
- Lippincott Williams & Wilkins, WK Health
- 10.1161/hyp.78.suppl_1.P172
- 0194-911X
- 1524-4563
- English
- 09/01/2021
- Academic
- Neuroscience and Pharmacology; Cardiovascular Medicine; Psychological and Brain Sciences; Internal Medicine; Iowa Neuroscience Institute; Neurology (Pediatrics)
- 9984256881302771
12