Abstract
Abstract P189: Long-term Blood Pressure Variability And Risk Of Cardiovascular Disease Events Among Community-dwelling Elderly
Hypertension (Dallas, Tex. 1979), Vol.76(Suppl_1)
09/2020
DOI: 10.1161/hyp.76.suppl_1.P189
Abstract
Greater blood pressure variability (BPV) in midlife increases risk of future cardiovascular disease (CVD) events, but the impact of BPV in adults who have reached older ages while remaining free of CVD is unknown. We examined risk of overall incident CVD, ischemic stroke subgroup, and all-cause mortality associated with long-term, visit-to-visit BPV in participants of the ASPirin in Reducing Events in the Elderly study, a randomized primary prevention trial of daily low-dose aspirin in community-dwelling adults in Australia and the United States (US) aged 70 and older (65 if US minority) without evidence of CVD. The mean of three blood pressures (BP) using an automated cuff was recorded at baseline and annually. CVD was a prespecified composite secondary endpoint of ASPREE, and included fatal coronary heart disease, nonfatal MI, fatal or nonfatal stroke, or hospitalization for heart failure. All CVD events were adjudicated as part of the main trial. This analysis included participants who survived without CVD to the second annual visit and had BP recorded at baseline, years 1 and 2 (n=16,482). BPV was defined as within-individual standard deviation of mean systolic BP across these visits. Cox proportional hazards regression adjusting for confounders was used to calculate hazard ratios (HR) according to tertile of estimated BPV, with year 2 as time zero to minimize immortal time bias. Our results (Table) show that higher visit-to-visit BPV in older adults without previous CVD is associated with increased risk of future CVD events, ischemic stroke, and all-cause mortality, suggesting that BPV in older ages should be considered a potential therapeutic target for CVD risk-lowering.
Details
- Title: Subtitle
- Abstract P189: Long-term Blood Pressure Variability And Risk Of Cardiovascular Disease Events Among Community-dwelling Elderly
- Creators
- Michael E Ernst - University of IowaEnayet K Chowdhury - Monash UniversityLawrie Beilin - University of Western AustraliaKaren L Margolis - HealthPartnersMark R Nelson - University of TasmaniaRory Wolfe - Monash UniversityAndrew Tonkin - Monash UniversityRobyn L Woods - Monash UniversityJohn J McNeil - Monash UniversityChristopher M Reid - Curtin University
- Resource Type
- Abstract
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.76(Suppl_1)
- DOI
- 10.1161/hyp.76.suppl_1.P189
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Pharmacy Practice and Science; Family Medicine
- Record Identifier
- 9984297651802771
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