Abstract
Abstract P194: Voluntary Exercise Eliminates Maternal Gestational Hypertension-induced Hypertensive Response Sensitization In Post-weaning High Fat Diet Fed Male Adult Offspring
Hypertension (Dallas, Tex. 1979), Vol.78(S_1), p.AP194
09/01/2021
DOI: 10.1161/hyp.78.suppl_1.P194
Abstract
Byline: Baojian Xue, UNIVERSITY OF IOWA, Iowa City, IA; Yang Yu, Univ of Iowa, Iowa City, IA; terry beltz, Univ of Iowa, Iowa City, IA; Fang Guo, Unversity of Iowa, Iowa City, IA; Shun-Guang Wei, UNIVERSITY OF IOWA, Iowa City, IA; David M Pollock, Univ of Alabama at Birmingham, Birmingham, AL; Jennifer S Pollock, UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL; Alan K Johnson, UNIVERSITY IOWA, Iowa City, IA Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. Our previous studies demonstrated that maternal gestational hypertension (MGHT) induces hypertensive response sensitization (HTRS) elicited by post-weaning high fat diet (HFD) in male offspring. The present study tested whether voluntary exercise would protect against MGHT-induced HTRS in HFD fed male offspring. Male offspring from both normotensive (NT) and MGHT dams were given access to either "blocked" (sedentary offspring) or functional running (exercised offspring) wheels for 10 weeks during normal fat diet (NFD) or HFD feeding. HFD feeding significantly increased resting blood pressure (BP) in sedentary offspring of both NT (112.3Ø0.7 to 119.9Ø1.2 mmHg, p<0.05) and MGHT (112.5Ø0.9 to 129.6Ø1.0 mmHg, p<0.05) dams, but the elevated BP induced by HFD was greater in sedentary offspring of MGHT dams (129.6Ø1.0 vs. 119.9Ø1.2 mmHg, p<0.05). The sedentary offspring of MGHT dams also displayed greater sympathetic tone and enhanced pressor responses to centrally administrated angiotensin (ANG) II or leptin. The running distance was comparable in four groups of exercise offspring (9.183Ø1.183, 9.192Ø1.677, 7.233Ø1.080, 8.482Ø1.455 kilometers/day, p>0.05). Voluntary exercise did not alter BP in NFD fed offspring and HFD fed offspring of NT dams, but it attenuated BP in HFD fed offspring of MGHT dams (129.6Ø1.0 to 121.1Ø0.8 mmHg, p<0.05) and body weight and heart rate in all offspring. Moreover, voluntary exercise significantly reduced sympathetic tone (Hexamethonium, ip, MAP ðö-50.6Ø1.0 to ðö-29.7Ø2.7 mmHg, p<0.05) and pressor responses to central ANG II and leptin in HFD fed offspring of both NT (ANG II: ðö16.0Ø0.9 to ðö7.5Ø1.1 mmHg; leptin: ðö11.8Ø0.6 to ðö5.4Ø0.9 mmHg, p<0.05) and MGHT (ANG II: ðö24.3Ø2.1 to ðö7.6Ø1.8 mmHg; leptin: ðö16.8Ø0.9 to ðö5.2Ø1.0 mmHg, p<0.05) dams and eliminated the differences in these responses between NFD fed offspring and HFD fed offspring. These results indicate that exercise training plays a beneficial role in preventing MGHT-induced HTRS and that this effect is associated with reduced brain reactivity to pressor stimuli and centrally driven sympathetic activity.
Details
- Title: Subtitle
- Abstract P194: Voluntary Exercise Eliminates Maternal Gestational Hypertension-induced Hypertensive Response Sensitization In Post-weaning High Fat Diet Fed Male Adult Offspring
- Creators
- Baojian Xue - University of IowaYang Yu - University of Iowaterry beltz - University of IowaFang Guo - University of IowaShun-Guang Wei - University of IowaDavid M Pollock - University of Alabama at BirminghamJennifer S Pollock - University of Alabama at Birmingham
- Resource Type
- Abstract
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.78(S_1), p.AP194
- Publisher
- Lippincott Williams & Wilkins, WK Health
- DOI
- 10.1161/hyp.78.suppl_1.P194
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 09/01/2021
- Description audience
- Academic
- Academic Unit
- Neuroscience and Pharmacology; Cardiovascular Medicine; Psychological and Brain Sciences; Internal Medicine; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984256794102771
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