Abstract
Abstract P196: Association Of Chronic Kidney Disease With Blood Pressure Severity And Target Organ Injury At Baseline In Youth Referred For Hypertension Disorders
Hypertension (Dallas, Tex. 1979), Vol.80(Suppl_1)
09/2023
DOI: 10.1161/hyp.80.suppl_1.P196
Abstract
Abstract only Youth with chronic kidney disease (CKD) are at risk for hypertension (HTN) and associated target organ injury (TOI). This population may need an alternate screening schedule for TOI. Our objective was to determine the association of CKD with TOI and blood pressure (BP) severity at baseline in youth referred for HTN disorders, hypothesizing that we would see lower BP severity and less cardiac TOI in youth with CKD. This is an interim analysis using baseline data from the SUPERHERO Registry, a multisite retrospective study of youth referred for HTN disorders. Inclusion criteria were age <19 years and HTN disorder identified by ICD-10 codes from 1/1/2015-12/31/2022 at initial visit to a subspecialty clinic. Exclusion criteria were kidney failure on dialysis, kidney transplantation, or pregnancy by ICD-10 codes. Our exposure was presence of CKD by ICD-10 code. Our outcomes were presence of TOI (kidney and/or heart) by ICD-10 codes and BP severity from in-clinic BP measurement. We unadjusted generalized linear models. Of 11,580 participants, 488 (4%) had a diagnosis of CKD (Table). Youth with CKD had significantly higher risk of kidney-specific TOI (RR 2.81; 95% CL 2.23 to 3.52) and significantly lower BP by BP classification (OR 0.68; 95% CL 0.57 to 0.81) and lower systolic BP in adolescents (β -5.7 mmHg; 95% CL -7.4 to -4.0). Our findings could reflect differential management of patients with established subspecialty care who develop HTN and have early TOI screening or are already on anti-hypertensive medication for proteinuria. Future steps include analyzing rates of TOI screening and laboratory and echocardiogram results for precision.
Details
- Title: Subtitle
- Abstract P196: Association Of Chronic Kidney Disease With Blood Pressure Severity And Target Organ Injury At Baseline In Youth Referred For Hypertension Disorders
- Creators
- Carol Vincent - Wake Forest UniversityJessica F Campbell - Texas Children's HospitalJackson Londeree - Atlanta, GAJason MisuracMaggie Murphy - University of KentuckyElizabeth Onugha - Baylor College of MedicineSandeep RiarChristine Sethna - North Shore Diabetes and Endocrine AssociatesSahar SiddiquiDonald J Weaver - Levine Children's HospitalIkuyo Yamaguchi - Children's Hospital of OklahomaAndrew South - Wake Forest University
- Resource Type
- Abstract
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.80(Suppl_1)
- DOI
- 10.1161/hyp.80.suppl_1.P196
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 09/2023
- Academic Unit
- Stead Family Department of Pediatrics; Nephrology, Dialysis and Transplantation
- Record Identifier
- 9984480137202771
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