Abstract
Abstract P229: The Associations Between Muscular Strengthening Activity, Physical Function, and All-Cause Mortality Among Older Adults With Cardiovascular Disease
Circulation (New York, N.Y.), Vol.147(Suppl_1), pp.AP229-AP229
02/28/2023
DOI: 10.1161/circ.147.suppl_1.P229
Abstract
Background: CVD is the leading cause of mortality in the US. Strong evidence suggests that aerobic physical activity (PA) is associated with reducing the risk of mortality among those with CVD. However, the extent to which muscular strengthening activity (MSA), as well as measures of physical functioning (PF), is related to mortality risk reduction is unknown in those with CVD.
Purpose: To examine the associations between MSA and PF with all-cause mortality among a representative sample of the US with CVD.
Methods: Participants aged ≥50 years (n=5,531; mean age 64.3 years, 52% female) from the 1999-2006 NHANES with complete covariates and outcomes were included. A subset (n=2,094) had MEC-measured PF data (time to peak force in seconds [TPF]; peak force in newtons [PF-N]; time to complete a 20-foot walk in seconds [TCW]) available at baseline through 2002. MSA volume was dichotomized as meeting (≥2 days/week) vs not meeting current MSA guidelines (<2 days/week). Multivariable Cox proportional hazards regression models estimated associations (HR) between (1) MSA categories, and (2) quartiles of PF [TPF, TCW, PN-F], with all-cause mortality in the overall sample, and then stratified by enrollment age (<50-64 years and ≥65 years).
Results: A total of 2,046 deaths from any cause were identified over the 69,386 person-years of follow-up. Null associations were observed between MSA categories with mortality in multivariable models. Age stratified models revealed lower risk of all-cause mortality in adults ≥65 years meeting MSA guidelines versus insufficient MSA (HR 0.85, 0.73-0.99); however this association was not observed in adults aged 50-64 (HR 1.17, 0.82-1.65). Dose-response reductions in all-cause mortality risk were found across all quartiles for TCW and PF-N but not for TPF. These findings were consistent in adults aged 50-64 years and ≥65 years.
Conclusions: Results suggest that meeting MSA recommendations is particularly beneficial for lowering all-cause mortality risk among those ≥65 years. Further, higher levels of PF appear to be associated with lower all-cause mortality risk among adults, supporting the role of assessing PF a potential indicator of future mortality risk. These findings collectively underscore the importance of including MSA in exercise prescriptions for older adults with CVD.
Details
- Title: Subtitle
- Abstract P229: The Associations Between Muscular Strengthening Activity, Physical Function, and All-Cause Mortality Among Older Adults With Cardiovascular Disease
- Creators
- William Boyer - California Baptist UniversityDeepika Laddu - University of Illinois at ChicagoJessica Gorzelitz - University of IowaRobert Booker - Northwestern University
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.147(Suppl_1), pp.AP229-AP229
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/circ.147.suppl_1.P229
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 02/28/2023
- Academic Unit
- Obstetrics and Gynecology; Health and Human Physiology
- Record Identifier
- 9984811216402771
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