Abstract
Abstract P271: Women’s Reproductive History and Peripheral Arterial Disease in Late Life: The San Diego Population Study
Circulation (New York, N.Y.), Vol.137(suppl_1)
03/20/2018
DOI: 10.1161/circ.137.suppl_1.p271
Abstract
Abstract only
Background:
Total population burden of peripheral artery disease (PAD) is higher for women than men age ≥40 years. Reproductive factors (e.g., early menarche, parity, early menopause) have been linked with later-life cardiovascular risk in women, but whether they influence PAD has been understudied.
Objective:
To evaluate associations between reproductive factors with later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques.
Methods:
Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study conducted in 2007-2011. Reproductive exposures included age at menarche, number of live births, age at menopause, surgical menopause, and history of oral contraceptive use. Dependent variables were ABI and Doppler ultrasound measurements of common fIMT and any femoral plaque presence. We performed multiple linear and logistic regression adjusting for age, race/ethnicity, and cardiometabolic factors. Since 30% (n=201) of women reported surgical menopause, we tested for interactions with reproductive factors and stratified by menopause type (natural vs. surgical).
Results:
Women were on average 70.6 years old (SD=9.6) and 56% were White. There were no significant associations in the overall sample after adjusting for covariates. We found interactions between surgical menopause and oral contraceptive use (p=0.03) for ABI, and with parity (p=0.05) and age at menopause (p=0.05) for fIMT. Among women with natural menopause, oral contraceptive use was associated with higher ABI (β:0.03, p=0.007) and older age at menopause was related to greater fIMT (β:0.009, p=0.06) (
Table 1
). Among women with surgical menopause, parity (0 vs. 2) was marginally associated with greater fIMT (β:0.33, p=0.07).
Conclusions:
Findings suggest that reproductive history may be associated with later-life development of PAD in women. Studies are necessary to confirm findings and examine pregnancy-related exposures in relation to PAD.
Details
- Title: Subtitle
- Abstract P271: Women’s Reproductive History and Peripheral Arterial Disease in Late Life: The San Diego Population Study
- Creators
- Yamnia I Cortes - University of PittsburghNisha Parikh - University of California, San FranciscoMatthew A Allison - University of California, San DiegoMichael H Criqui - University of California, San DiegoNatalie Suder - University of PittsburghEmma Barinas-Mitchell - University of PittsburghChristina L Wassel - University of Pittsburgh
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.137(suppl_1)
- DOI
- 10.1161/circ.137.suppl_1.p271
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 03/20/2018
- Academic Unit
- Nursing
- Record Identifier
- 9984446734602771
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