Abstract
Abstract P324: Clinical Outcomes And 30-day Readmissions For Heart Failure With Preserved Ejection Fraction And Cardiorenal Syndrome: A Multicenter Database Analysis
Hypertension (Dallas, Tex. 1979), Vol.79(Suppl_1)
09/2022
DOI: 10.1161/hyp.79.suppl_1.P324
Abstract
Abstract only
Background:
Literature regarding cardiorenal syndrome (CRS) outcomes among heart failure with preserved ejection fraction (HFpEF) is limited.
Objective:
This study sought to characterize CRS patients' clinical outcomes and 30-day readmission rates with HFpEF.
Methods:
Data was collected from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project (HCUP) Nationwide Readmissions Database (NRD) from January 1, 2018, to November 30, 2019. We used the International Classification of Diseases, 10
th
revision (ICD-10) diagnostic codes to identify encounters with CRS related to HFpEF.
Results:
Out of the 1,530,749 index HFpEF-CRS related hospitalizations (mean age 74.44±12.42years; 56.7%females), 1,295,302(82.1%) had CKD stage I-IV and 281,689(17.9%) had CKD stage V+. The CKD I-IV+ group had higher multi-organ complications including atrial fibrillation (AF) (33.7% vs 21.1%; p-value <0.001), acute kidney injury (AKI) (53.2% vs 20.1%; p-value <0.001), AKI requiring hemodialysis (53.2% vs 20.1%; p-value <0.001), respiratory failure (36.2% vs 34%, p-value <0.001), and ischemic stroke (2.21% vs 2%, p-value <0.001). However, the all-cause mortality for CRS with CKD V+ was higher as compared to CRS with CKD I-IV (4.83% vs 4.39%; p <0.001). HFpEF with CKD V+ had a significantly higher 30-day readmission rates compared to CKD I-IV subgroup (40.6% vs 15.8%; p-value <0.001). The predominant etiologies associated with 30-day readmissions among CKD I-IV in comparison to CKD V+ include cardiopulmonary (54.2%vs48.8%), and infectious (10.7%vs11.3%) diseases.
Conclusion:
Among HFpEF-CRS hospital encounters, progression of CKD stages is associated with higher 30-day readmission rates and all-cause mortality. These factors are accountable for a substantially increased healthcare burden. These findings suggest that regardless of CKD stages, patients with CRS should be monitored vigilantly during hospital admissions to avoid life-threatening complications.
Details
- Title: Subtitle
- Abstract P324: Clinical Outcomes And 30-day Readmissions For Heart Failure With Preserved Ejection Fraction And Cardiorenal Syndrome: A Multicenter Database Analysis
- Creators
- Layla Shanah - Wayne State UniversityTanveer Mir - Wayne State UniversityMohammed Uddin - Detroit Med Cntr, Detroit, MITanveer Hussain - SummaHealth, Akron, OHTilachan Parajuli - Brookwood Baptist HealthZeenat Y Bhat - Wayne State University
- Resource Type
- Abstract
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.79(Suppl_1)
- DOI
- 10.1161/hyp.79.suppl_1.P324
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 09/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985013724902771
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