Abstract P511: Adherence to the Dietary Portfolio is Associated With Lower Cardiovascular Disease Risk in the Women's Health Initiative Study

Andrea J Glenn; Kenneth Lo; Beatrice A Boucher; Mara Z Vitolins; Joann E Manson; Linda G Snetselaar; Cyril W Kendall; David J Jenkins; Simin Liu; John L Sievenpiper

doi:10.1161/circ.141.suppl_1.P511

Abstract

Abstract P511: Adherence to the Dietary Portfolio is Associated With Lower Cardiovascular Disease Risk in the Women's Health Initiative Study

Andrea J Glenn, Kenneth Lo, Beatrice A Boucher, Mara Z Vitolins, Joann E Manson, Linda G Snetselaar, Cyril W Kendall, David J Jenkins, Simin Liu and John L Sievenpiper

Circulation (New York, N.Y.), Vol.141(Suppl_1)

03/03/2020

DOI: 10.1161/circ.141.suppl_1.P511

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Abstract

Introduction: The Dietary Portfolio is a plant-based dietary pattern of a combination of recognized cholesterol-lowering foods and has been shown to lower a number of cardiovascular disease (CVD) risk factors, including low-density lipoprotein cholesterol, blood pressure and C-reactive protein. However, no studies have assessed if following the Portfolio results in fewer CVD events. Hypothesis: Higher adherence to the Portfolio will be associated with fewer CVD events. Methods: We included 125,389 postmenopausal women from the Women’s Health Initiative Observational Study and Clinical Trials (from 1993 to 2017) who were free of CVD at baseline. Adherence to the Portfolio was assessed using an a priori diet index based on 6 food categories (high in plant protein [soy & pulses], nuts, viscous fiber, plant sterols and monounsaturated fat, and low in saturated fat) that were found to lower CVD risk factors in the Portfolio trials. Adjusted hazard ratios (HRs) and 95% confidence intervals [CIs] for CVD were calculated using Cox regressions. We adjusted for CVD risk & lifestyle factors and potential confounders (see Table 1). Results: During 1,826,176 person-years of follow-up, we documented 11,370 total CVD cases, including 5,739 coronary heart disease (CHD) cases, 4,451 stroke cases, 1,946 heart failure (HF) cases and 935 atrial fibrillation (AF) cases. Comparing the highest to the lowest quartile in the fully adjusted model, higher adherence to the Portfolio was associated with a reduced risk of total CVD (HR=0.89 [95% CI 0.84-0.95]), CHD (0.87 [0.79-0.95]) and HF (0.83 [0.70-0.98]). No association was found with stroke (0.97 [0.87-1.08]) and AF (1.09 [0.87-1.38]). Conclusions: In postmenopausal women, higher adherence to the Portfolio was inversely associated with total CVD, CHD and HF but not stroke or AF. These findings suggest that the Portfolio may assist with CVD, CHD and HF prevention and warrants further investigation. Table 1: Association of the Dietary Portfolio and risk of CVD in Postmenopausal Women

Details

Title: Subtitle: Abstract P511: Adherence to the Dietary Portfolio is Associated With Lower Cardiovascular Disease Risk in the Women's Health Initiative Study
Creators: Andrea J Glenn - Univ of Toronto, Toronto, Canada
Kenneth Lo - Brown Univ, Provincetown, RI
Beatrice A Boucher - Univ of Toronto, Toronto, Canada
Mara Z Vitolins - Med Cntr Boulevard, Salem, NC
Joann E Manson - HARVARD MEDICAL SCHOOL, Boston, MA
Linda G Snetselaar - Univ Iowa, Iowa City, IA
Cyril W Kendall - Univ of Toronto, Toronto On, Canada
David J Jenkins - Univ of Toronto, Toronto, Canada
Simin Liu - Brown Univ, Providence, RI
John L Sievenpiper - Univ of Toronto, Toronto, Canada
Resource Type: Abstract
Publication Details: Circulation (New York, N.Y.), Vol.141(Suppl_1)
DOI: 10.1161/circ.141.suppl_1.P511
ISSN: 0009-7322
eISSN: 1524-4539
Language: English
Date published: 03/03/2020
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984216626602771

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