Abstract
Abstract P75: Cerebrovascular Events and Outcomes in Hospitalized Patients With Covid-19: The Society of Vascular and Interventional Neurology Multinational Registry
Stroke (1970), Vol.52(Suppl_1), p.AP75
03/2021
DOI: 10.1161/str.52.suppl_1.P75
Abstract
Background:
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients.
Aims:
To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease.
Methods:
Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in 4 countries (2/1/2020 - 06/16/2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST).
Results:
Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970-1320/100,000), 68/171 (40.5%) of whom were female and 96/172 (55.8%) were between the ages 60-79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920-1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130 - 280/100,000) and 3 with CVST (0.02%; 20/100,000, 95%CI 4-60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p<0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63-15.44, p<0.01), older age (aOR 1.78, 95%CI 1.07-2.94, p=0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34-0.98 p=0.04) were the only independent predictors of mortality among patients with stroke and COVID-19.
Conclusions:
COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19 associated cerebrovascular complications, therefore aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
Details
- Title: Subtitle
- Abstract P75: Cerebrovascular Events and Outcomes in Hospitalized Patients With Covid-19: The Society of Vascular and Interventional Neurology Multinational Registry
- Creators
- James E Siegler - Cooper University HospitalPere Portela - Bellvitge University HospitalJuan F Arenillas - Hospital Clínico Universitario de ValladolidAlba Chavarria-Miranda - Hospital Clínico Universitario de ValladolidAna Guillen - Bellvitge University HospitalMercedes de Lera - Hospital Clínico Universitario de ValladolidPriyank Khandelwal - Johnson UniversityIvo Bach - Johnson UniversityPratit Patel - Johnson UniversityAmit Singla - Johnson UniversityManuel Requena - Autonomous University of BarcelonaMarc Ribo - HOSPITAL VALL D HEBRON, BarcelonaDinesh V Jillella - Emory UniversityRaul G Nogueira - Emory UniversityDiogo C Haussen - Grady Memorial HospitalAlejandro R Vazquez - Consorci Institut D'Investigacions Biomediques August Pi I SunyerXabier Urra - Dept of Neurology, Hosp Clínic, Barcelona, SpainLuis San Roman - Dept of Radiology, Hosp Clínic, Barcelona, SpainJesse M Thon - Cooper University HospitalRyna Then - Cooper University HospitalNatalia Perez de la Ossa - Stroke Unit, Neuroscience Dept, Hosp Universitari Germans Trias i Pujol, Carretera Canyet s/n, 08916 Badalona, Barcelona, SpainMonica Millan - Germans Trias i Pujol, BadalonaOssama Mansour - Alexandria UniversityCristina Tiu - Carol Davila University of Medicine and PharmacyThanh Nguyen - Boston UniversityArtem Kaliaev - Boston UniversityAlexandra L Czap - University of Texas at Houston, Houston, TXAlicia Zha - UT Health Science Cntr Houston, Houston, TXDavid S Liebeskind - University of California, Los AngelesSantiago Ortega-Gutierrez - University of IowaMudassir Farooqui - University of IowaAmeer E Hassan - Valley Baptist Medical CenterSaif Bushnaq - Bon Secours Mercy HealthOsama O Zaidat - Mercy St. Vincent Medical CenterTudor G Jovin - Cooper Neurological Institute, Camden, NJ
- Resource Type
- Abstract
- Publication Details
- Stroke (1970), Vol.52(Suppl_1), p.AP75
- DOI
- 10.1161/str.52.suppl_1.P75
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 03/2021
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984303558602771
Metrics
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