Abstract
Abstract TP216: Sex-Based Differences in Endovascular Thrombectomy Outcomes for Large Ischemic Stroke: A SELECT2 Subanalysis
Stroke (1970), Vol.55(Suppl_1)
02/2024
DOI: 10.1161/str.55.suppl_1.TP216
Abstract
Abstract only Introduction: Multiple randomized controlled trials demonstrated better functional outcomes with endovascular therapy (EVT). Potential heterogeneity in EVT treatment effect by sex is an important question as several social and biological factors are shown to differentially affect stroke outcomes between men and women. We aimed to evaluate if clinical outcomes and thrombectomy treatment effect differed by sex among patients with large ischemic stroke. Methods: In the SELECT2 RCT, baseline characteristics and outcomes were compared between men and women. The primary outcome was a shift in modified Rankin Scale score, with functional independence (mRS 0-2), independent ambulation (mRS 0-3) and symptomatic ICH as secondary outcomes. Effect modification was examined using multiplicative sex-by-treatment interaction term. Additionally, repeated measure mixed effect models were used to evaluate if recovery in functional status differed by sex at discharge/ 5 to7-day, 30-day, and 90-day follow-up. Results: Of 352 enrolled patients, 71/145 (49%) of women and 109/207 (53%) of men underwent EVT. EVT was uniformly associated with better functional outcomes without evidence of treatment effect modification [Men - aGenOR: 1.66(1.24-2.23) vs women - aGenOR: 1.73(1.22-2.45), p-int: 0.94], functional independence [men - aRR: 1.99(0.99-4.02) vs women - aRR: 5.04(1.59-16.02), p-int: 0.20] and independent ambulation [men - aRR: 1.98(1.29-3.03) vs women - aRR: 2.44(1.40-4.24), p-int: 0.67]. There were no significant differences between the two cohorts’ recovery at discharge/5 to 7-day, 30-day, and 90-day follow-up (figure). Conclusions: EVT was associated with higher rates of functional independence and independent ambulation in both men and women, without significant heterogeneity in treatment effect or recovery arc between discharge and 90-day follow-up. Trial Registration: NCT03876457
Details
- Title: Subtitle
- Abstract TP216: Sex-Based Differences in Endovascular Thrombectomy Outcomes for Large Ischemic Stroke: A SELECT2 Subanalysis
- Creators
- Jenny P Tsai - Cleveland ClinicThanh Nguyen - Boston Medical CenterFifi T Johanna - Icahn School of Medicine at Mount SinaiSophia Sundararajan - University Hospitals of ClevelandJoanna D Schaafsma - Toronto Western HospitalNatalia Perez de la Ossa - TriasMichael G Abraham - University of KansasMichael Chen - Rush UniversityMuhammad S Hussain - Cleveland ClinicSantiago Ortega-Gutierrez - University of IowaHannah Johns - Royal Melbourne HospitalAmanda Opaskar - University Hospitals of ClevelandKelsey R Duncan - University Hospitals of ClevelandLeonid Churilov - Royal Melbourne HospitalDeep Pujara - University Hospitals of ClevelandFaris Shaker - The University of Texas Health Science Center at HoustonMohammad A Abdulrazzak - Cleveland ClinicJames C Grotta - Memorial HermannVitor Mendes Pereira - St. Michael's HospitalMichael D Hill - University of CalgaryMarc Ribo - Vall d'Hebron Hospital UniversitariAmeer E Hassan - Valley Baptist Medical CenterCathy A Sila - University Hospitals of ClevelandBruce Campbell - Royal Melbourne HospitalAmrou Sarraj - University Hospitals of ClevelandSELECT2 Investigators
- Resource Type
- Abstract
- Publication Details
- Stroke (1970), Vol.55(Suppl_1)
- DOI
- 10.1161/str.55.suppl_1.TP216
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 02/2024
- Academic Unit
- Neurosurgery; Radiology; Neurology
- Record Identifier
- 9984557859502771
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