Abstract
Abstract TP89: Ldl Levels May Correlate With Intracranial Atherosclerotic Plaque Enhancement
Stroke (1970), Vol.54(S_1), p.ATP89
02/01/2023
DOI: 10.1161/str.54.suppl_1.TP89
Abstract
Byline: Sebastian Sanchez, Neurology, Univeristy of Iowa, Iowa city, IA; Jacob M Miller, Neurology, Univ of Iowa, Iowa City, IA; Matthew T Jones, Neurology, Univ of Iowa, Iowa City, IA; Edgar A Samaniego, Neurology, Radiology and Neurosurgery, Univ of Iowa, Iowa City, IA Introduction: The enhancement of atherosclerotic plaques after the intravenous administration of gadolinium (Gd) has been correlated with the presence of culprit plaques in patients with acute strokes due to underlying intracranial atherosclerosis (ICAS). A new method to objectively quantify Gd-enhancement was used to monitor plaques over time after an acute stroke. Currently there is no imaging method to accurately monitor atherosclerotic activity. Methods: Patients with stroke or transient ischemic attack caused by ICAS were included. Every patient was started on high-dose statins after ictus. 7T MRI images were obtained at baseline and after at least 6 months. LDL levels were obtained at the time of the event and at follow-up. Culprit plaques were identified based on degree of stenosis, presence of positive remodeling and Gd-enhancement. Arterial 3D enhancement maps in the territory of the culprit plaque were generated. Orthogonal signal intensity (SI) probes were expanded into the plaque and parent vessel to generate 3D enhancement color maps. Arterial segment variance (ASV) (SD2Arterial segment Baseline T1+Gd - SD2Arterial segment Follow up T1+Gd) was used to compare the plaque and parent vessel enhancement. Results: Five patients underwent baseline and follow-up imaging. The median time between scans was 13.3 (IQR=13.3) months. ASV was strongly correlated with changes in LDL (Rho=0.9, p=0.037). Additionally, Gd-enhancement and plaque burden correlated with levels of LDL (Figure): Gd uptake (Rho=0.7, p=0.22) and plaque burden (Rho=0.67, p=0.22). Conclusion: This pilot study demonstrates that high-resolution imaging can be used in determining the response to statins in patients with high atherosclerotic burden. Gd-enhancement and plaque burden correlated with serum values of LDL. 3D enhancement maps and histogram analysis of atherosclerotic plaques are promising tools for evaluating disease activity and response to medical therapy.
Details
- Title: Subtitle
- Abstract TP89: Ldl Levels May Correlate With Intracranial Atherosclerotic Plaque Enhancement
- Creators
- Sebastian Sanchez - University of IowaJacob M Miller - University of IowaMatthew T Jones - University of IowaEdgar A Samaniego - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Stroke (1970), Vol.54(S_1), p.ATP89
- Publisher
- Lippincott Williams & Wilkins, WK Health
- DOI
- 10.1161/str.54.suppl_1.TP89
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 02/01/2023
- Description audience
- Academic
- Academic Unit
- Surgery; Orthopedics and Rehabilitation; Neurosurgery; Radiology; Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984367715502771
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