Abstract
Abstract WP047: Incidental Cerebral Aneurysms in Patients with Cervical Artery Dissection
Stroke (1970), Vol.57(Suppl_1)
02/2026
DOI: 10.1161/str.57.suppl_1.WP047
Abstract
Background: Patients with cervical artery dissection (CAD) have a higher prevalence of cerebral aneurysms, likely due to underlying vasculopathies. Understanding risk factors and outcomes in this population may inform screening and management strategies.
Methods: We conducted a post-hoc analysis of the STOP-CAD study, a multicenter international registry of patients with non-major trauma-related CAD across 63 centers. Cerebral aneurysms were identified based on medical history and intracranial vascular imaging obtained for dissection diagnosis. We compared demographic, clinical, laboratory, and imaging characteristics between patients with and without aneurysms. Variables with p<0.05 in univariate analysis were entered into a multivariable binary logistic regression to identify independent predictors. Clinical outcomes including ischemic stroke and symptomatic intracranial hemorrhage at follow-up were compared between both groups.
Results: Out of 4023 patients included in the STOP-CAD study, 116 (2.9%) had at least one incidental cerebral aneurysm. In adjusted binary logistic regression, patients with cerebral aneurysm were more likely to have a history of migraine (aOR 1.78 95% CI 1.15-2.75, p=0.009), history of hypertension (aOR 1.65 95% CI 1.12-2.43, p = 0.010), known connective tissue disorder (aOR 3.47 95% CI 1.71-7.03), history of dissection (aOR 2.63 95% CI 1.31-5.28, p = 0.007), and a dissecting aneurysm at the site of the dissection (aOR 1.94 95% CI 1.25-3.01, p = 0.003). At follow-up, the presence of a cerebral aneurysm was not associated with ischemic stroke (7.8% vs. 5.6% p>0.1), but with a trend towards increased odds of symptomatic intracranial hemorrhage (3.4% vs. 1.2%, p = 0.062).
Conclusions: Patients with CAD and concurrent incidental cerebral aneurysm were more likely to have a history of migraine headaches and markers of underlying vasculopathy and had a non-significantly increased risk of intracranial hemorrhage at follow-up. Further studies are needed to identify best practices for surveillance and risk stratification in this subgroup.
Details
- Title: Subtitle
- Abstract WP047: Incidental Cerebral Aneurysms in Patients with Cervical Artery Dissection
- Creators
- Christoph Stretz - Brown UniversityLiqi Shu - Brown UniversityDaniel Mandel - University of BridgeportEdgar Samaniego - University of IowaThanh Nguyen - Boston UniversityDavid Liebeskind - UCLA HealthChristopher Leon Guerrero - Carolinas Medical CenterMirjam Heldner - University Hospital of BernMarcel Arnold - University Hospital of BernSetareh Salehi Omran - University of Colorado DenverAhmad Nehme - Université de Caen NormandieJoao Sousa - University of CoimbraMuhib Khan - Mayo ClinicAaron Rothstein - University of PennsylvaniaStefan Engelter - University of BaselDiana Aguiar De Sousa - Lisbon Central University Hospital, Lisboa, PortugalThalia Field - University of British ColumbiaRonen Leker - Hadassah Medical CenterVishnu Dantu - Barrow Neurological InstituteRichard Choi - University of DelawareMalik Ghannam - University of IowaAlexandre Poppe - Centre Hospitalier de l’Université de MontréalAna Catarina Fonseca - Hospital de Santa MariaMichele Romoli - Ospedale “M. Bufalini” di CesenaZafer Keser - Mayo ClinicJennifer Frontera - NYU Langone Hospitals, Brooklyn, New York, United StatesMarialuisa Zedde - Azienda Sanitaria Unità Locale di Reggio EmiliaBrian MacGrory - Duke UniversitySami Al Kasab - Medical University of South CarolinaEkaterina Bakradze - University of Alabama at BirminghamMarc Rodrigo-Gisbert - Vall d'Hebron Hospital UniversitariFaddi Saleh Velez - University of OklahomaVenugopalan Vishnu - All India Institute of Medical Sciences RaipurSridhara Yaddanapudi - University of Maryland, BaltimoreAdeel Zubair - Yale UniversityJoao Pedro Marto - Hospital de Egas MonizPiers Klein - Boston UniversitySheila Martins - Hospital de Clínicas de Porto AlegreBalaji Krishnaiah - University of Tennessee at KnoxvilleCheran Elangovan - University of Tennessee Health Science CenterAbid Qureshi - University of Kansas Medical CenterMarina Mannino - Ospedale Vincenzo CervelloSOFIA Vasilopoulou - National and Kapodistrian University of AthensMohammed Sarvath - West Virginia UniversityTareq Kass-Hout - University of ChicagoShayak Sen - Cedars-Sinai Medical CenterMarwa Elnazeir - University of LouisvilleFarhan Khan - Brown UniversityKaren Furie - Brown UniversityShadi Yaghi - Hackensack Meridian Health
- Resource Type
- Abstract
- Publication Details
- Stroke (1970), Vol.57(Suppl_1)
- DOI
- 10.1161/str.57.suppl_1.WP047
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Publisher
- Lippincott Williams & Wilkins
- Language
- English
- Date published
- 02/2026
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9985132082202771
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