Abstract
Abstract WP184: Intravenous Thrombolysis Improves Outcomes in Stroke Patients With Unsuccessful Mechanical Thrombectomy
Stroke (1970), Vol.55(Suppl_1)
02/2024
DOI: 10.1161/str.55.suppl_1.WP184
Abstract
Abstract only Introduction: The benefits of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients with unsuccessful mechanical thrombectomy (MT) are not well established. Methods: This study included patients from the Stroke Thrombectomy and Aneurysm Registry (STAR) who underwent MT for ICA, M1, or M2 occlusions with unsuccessful MT (mTICI score ≤ 2a). Patients who received IVT prior to MT were compared to those who received MT alone. Propensity score (PS) matching was performed using age, sex, premorbid modified Rankin Scale (mRS), admission National Institute of Health Stroke Scale (NIHSS), occluded vessel, ASPECTS score, mTICI score, and symptom onset to groin puncture time. The primary outcome was favorable 90-day outcomes (mRS 0-2). Results: Of 610 patients with unsuccessful MT, 219 were matched in each group. Median ages were 70 [IQR: 61 - 80] and 73 [IQR: 62 - 81] in the IVT + MT and MT alone groups, respectively. In the IVT + MT group. Final TICI scores of 0, 1, and 2a were achieved in 92 (42.0%), 33 (15.1%), and 94 (42.9%) patients, respectively, compared to 76 (34.7%), 29 (13.2%), and 114 (52.1%) in the MT alone group. The IVT + MT group showed a significantly. higher 90-day mRS of 0-2 (aOR: 2.54, 95% CI: 1.53-4.32) and mRS of 0-3 (aOR: 2.05, 95% CI: 1.36-3.12). There were no significant differences between the groups in intracranial hemorrhage (ICH), symptomatic ICH, or 90-day mortality rates. Conclusions: IVT is associated with improved functional outcomes in patients with unsuccessful MT. Ensuring that IVT is provided to all eligible stroke patients should remain a priority.
Details
- Title: Subtitle
- Abstract WP184: Intravenous Thrombolysis Improves Outcomes in Stroke Patients With Unsuccessful Mechanical Thrombectomy
- Creators
- Sameh S Elawady - Medical University of South CarolinaNoah Nawabi - Medical University of South CarolinaHidetoshi Matsukawa - Medical University of South CarolinaConor Cunningham - Medical University of South CarolinaMohammad Mahdi Sowlat - University of South CarolinaAtakan Orscelik - Medical University of South CarolinaSara Zandpazandi - Medical University of South CarolinaIlko Maier - Universitätsmedizin GöttingenSami Al Kasab - Medical University of South CarolinaPascal M Jabbour - Thomas Jefferson UniversityJoon-Tae Kim - Chonnam National UniversityStacey C Quintero - Wake Forest Universityansaar rai - West Virginia UniversityRobert Starke - University of Miami Health SystemMarios Psychogios - University Hospital of BaselEdgar A Samaniego - University of IowaAdam S Arthur - Semmes Murphey FoundationShinichi Yoshimura - Hyogo Medical UniversityHugo Cuellar - Louisiana State University Health Sciences Center ShreveportBrian Howard - Emory UniversityAli Alawieh - Emory UniversityDaniele G. Romano - Ospedali Riuniti San Giovanni di Dio e Ruggi d'AragonaOmar Tanweer - Baylor College of MedicineJustin Mascitelli - The University of Texas Health Science Center at San AntonioIsabel Fragata - Unidade Local de Saúde de São JoséAdam Polifka - University of FloridaJoshua Osbun - Washington University in St. LouisRoberto CrosaCharles C Matouk - Yale UniversityMin S Park - University of VirginiaMichael Levitt - University of WashingtonWaleed Brinjikji - Mayo Clinic in ArizonaMark Moss - Washington Regional Medical CenterTravis Dumont - University of ArizonaRichard Williamson - Allegheny General HospitalPedro Navia - Hospital Universitario La PazPeter Kan - The University of Texas Medical Branch at GalvestonReade A De Leacy - Mount Saint Vincent UniversityShakeel A Chowdhry - NorthShore University HealthSystemAlejandro M Spiotta - Medical University of South CarolinaMohamad Ezzeldin - Lone Star College Kingwood
- Resource Type
- Abstract
- Publication Details
- Stroke (1970), Vol.55(Suppl_1)
- DOI
- 10.1161/str.55.suppl_1.WP184
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 02/2024
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984557941902771
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