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Acute To Chronic Pain Signatures (A2CPS) Thoracic Enrollment
Abstract   Open access   Peer reviewed

Acute To Chronic Pain Signatures (A2CPS) Thoracic Enrollment

Emine O. Bayman, Leigh Nadel, Christopher Coffey, Kathleen Sluka, Dana L. Dailey, Robert McCarthy and Chad Brummett
The journal of pain, Vol.24(4), pp.4-4
04/2023
DOI: 10.1016/j.jpain.2023.02.035
url
https://doi.org/10.1016/j.jpain.2023.02.035View
Published (Version of record) Open Access

Abstract

Acute to chronic pain signatures (A2CPS) is a prospective observational study which aims to characterize the predictive nature of biomarkers (brain imaging, blood screening, quantitative sensory testing, patient-reported outcome, and functional assessments) to identify individuals who will develop chronic pain following surgical intervention in total knee arthroplasty (TKA) and thoracic surgery cohorts. The original plan was each of the multisite clinical center (MCC) to recruit their own cohort of 1400 participants. Due to slow recruitment, both MCC's are enrolling participants from both cohorts. Recruitment for the TKA cohort is on target. However, recruitment for the thoracic surgery cohort is challenging in both MCCs. The purpose of this presentation was to describe the recruitment rate for patients undergoing thoracic surgery from the A2CPS Consortium to that of other published thoracic surgery studies. Sixteen randomized clinical trials (n=6) or prospective observational studies (n=10) of chronic pain after thoracic surgery were published between 2002 and 2017. None of these studies conducted brain imaging. Enrollment/month has averaged 6 patients at the University of Michigan, and 9 from the MCC2 sites throughout Michigan. It was 1.3 to 19 patients across the studies from the literature. Random effect estimate from meta-analysis for enrollment/month across the studies was 6.8 (95% CI: 5.1 to 8.5). Even though brain imaging is conducted at baseline and at 3 months in A2CPS, which generally increases the study complexity and requires an extra research visit, thoracic surgery enrollment/month in A2CPS was not lower than thoracic surgery enrollment from the literature. The A2CPS Consortium is supported by the NIH Common Fund, which is managed by the Office of Strategic Coordination (OSC). Consortium components include: Clinical Coordinating Center (U01NS077179), Data Integration and Resource Center (U01NS077352), Omics Data Generation Centers (U54DA049116, U54DA049115, U54DA09113), Multisite Clinical Center 1 (UM1NS112874), and Multisite Clinical Center 2 (UM1NS118922).

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