Abstract
Acute to Chronic Pain Signatures Program (a2CPS): Implementation of Remote Training for a Multisite Observation Study During COVID-19
The journal of pain, Vol.23(5), pp.5-6
05/2022
DOI: 10.1016/j.jpain.2022.03.021
Abstract
Chronic pain produces the largest non-fatal burden of disease, yet our understanding of factors that contribute to the transition from acute chronic pain are poorly understood. The Acute to Chronic Pain Signatures Program (A2CPS) is a longitudinal, multi-site observational study to identify biomarkers (individual or biosignature combinations) that predict susceptibility or resilience to the development of chronic pain after surgery (knee replacement or thoracotomy). Due to the COVID-19 pandemic, however, travel between sites was restricted just as the study was preparing to begin enrollment. Here, we present multiple training protocol adaptations that were successfully implemented to facilitate remote research-related training. The A2CPS consortium includes 2 Multisite Clinical Centers (MCCs, 10 recruitment sites), a Clinical Coordinating Center (CCC), a Data Integration and Resource Center (DIRC), 3 Omics Data Generation Centers, and representation from the NIH Pain Consortium, Common Fund, and National Institute of Drug Abuse. The A2CPS is collecting candidate and exploratory biomarkers including pain, fatigue, function, sleep, psychosocial factors, quantitative sensory testing (QST), genomics, proteomics, metabolomics, lipidomics, and brain imaging. The CCC adapted the A2CPS training and evaluation techniques for certifying the MCCs to ensure competency with recruitment, assessments (surveys, QST, function), and data entry across clinical sites using a combination of virtual training sessions, standardized quantitative measurements, video demonstrations, and reliability assessments. Staff at data collection sites have been successfully certified in all psychophysical assessments (QST, function). This included use of stop watches and metronomes to ensure standard application rates, completion of application-rate and inter-rater-reliability worksheets at each clinical site, designation of site-specific master examiners, training rubrics and video demonstration to verify competency was harmonized across sites. Adaptation of training protocols to a remote format enabled initiation of subject enrollment while maintaining documented standards with high data completion rates for surveys and assessments. The A2CPS Consortium is supported by the National Institutes of Health Common Fund, which is managed by the OD/Office of Strategic Coordination (OSC). Consortium components include: Clinical Coordinating Center (UO1NS077179), Data Integration and Resource Center (UO1NS077352), Omics Data Generation Centers (U54DA049116, U54DA049115, U54DA09113), and Multisite Clinical Centers: MCC 1 (UM1NS112874) and MCC 2 (UM1NS118922). Postdoctoral support for GB provided by the National Institutes of Neurological Disease and Stroke (NINDS) of the NIH under Award Number U24NS112873-03S2.
Details
- Title: Subtitle
- Acute to Chronic Pain Signatures Program (a2CPS): Implementation of Remote Training for a Multisite Observation Study During COVID-19
- Creators
- Giovanni Berardi - University of IowaLaura Frey-Law - University of IowaCarol GT Vance - University of IowaEmine O. Bayman - University of IowaChristopher S. Coffey - University of IowaDana L. Dailey - University of IowaDixie Ecklund - University of IowaKathleen A. Sluka - University of IowaTessa Balach - University of IowaJohn Burns - University of IowaAsokumar Buvanendran - University of IowaJoshua Jacobs - University of IowaRobert J. McCarthy - University of IowaRichard Wixson - University of IowaXiaohong Joe Zhou - University of IowaChad M. Brummett - University of IowaAndrew Chang - University of IowaDaniel Clauw - University of IowaDouglas Colquhoun - University of IowaRichard E. Harris - University of IowaSteven Harte - University of IowaJennifer Waljee - University of IowaDavid A. Williams - University of IowaPanshak Dakup - University of IowaOliver Fiehn - University of IowaKathleen M. Fisch - University of IowaTimothy D. Howard - University of IowaJon M. Jacobs - University of IowaKristen Jepsen - University of IowaCarl D. Langefeld - University of IowaLouise C. Laurent - University of IowaAnna Lokshin - University of IowaMichael Olivier - University of IowaWei-Jun Qian - University of IowaAdam C. Swensen - University of IowaBrian Caffo - University of IowaCiprian Crainiceanu - University of IowaJames Ford - University of IowaAri Kahn - University of IowaMartin Lindquist - University of IowaStephani P. Sutherland - University of IowaMargaret Taub - University of IowaTor Wager - University of IowaNicolas Johnston - University of IowaLaura D. Wandner - University of IowaThe Acute to Chronic Pain Signatures Consotrium
- Resource Type
- Abstract
- Publication Details
- The journal of pain, Vol.23(5), pp.5-6
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpain.2022.03.021
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Language
- English
- Date published
- 05/2022
- Academic Unit
- Anesthesia; Biostatistics; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Nursing; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984256770402771
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