Abstract
Adenylate kinase phosphotransfer communicates cellular energetic signals to KATP channels
Journal of molecular and cellular cardiology, Vol.33(6), pp.A18-A18
06/2001
DOI: 10.1016/S0022-2828(01)90070-7
Abstract
Transduction of energetic signals into membrane electrical events governs vital cellular functions, ranging from hormone secretion and cytoprotection to appetite control and hair growth. Central to the regulation of such diverse cellular processes are the metabolism sensing ATP-sensitive K+ (KATP) channels. However, the mechanism that communicates metabolic signals and integrates cellular energetics with KATP channel-dependent membrane excitability remains elusive. Here, we identify that the response of KATP channels to metabolic challenge is regulated by adenylate kinase phosphotransfer. Adenylate kinase associates with the KATP channel complex, anchoring cellular phosphotransfer networks and facilitating delivery of mitochondrial signals to the membrane environment. Deletion of the adenylate kinase gene compromised nucleotide exchange at the channel site and impeded communication between mitochondria and KATP channels, rendering cellular metabolic sensing defective. Assigning a signal processing role to adenylate kinase identifies a phosphorelay mechanism essential for efficient coupling of cellular energetics with KATP channels and associated functions.
Details
- Title: Subtitle
- Adenylate kinase phosphotransfer communicates cellular energetic signals to KATP channels
- Creators
- A.J CarrascoP.P DzejaA.E AlekseevD PucarL.V ZingmanM.R Abraham'D HodgsonM BienengraeberM PuceatE JanssenBe WieringaA Terzic
- Resource Type
- Abstract
- Publication Details
- Journal of molecular and cellular cardiology, Vol.33(6), pp.A18-A18
- DOI
- 10.1016/S0022-2828(01)90070-7
- ISSN
- 0022-2828
- eISSN
- 1095-8584
- Language
- English
- Date published
- 06/2001
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094498302771
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