Abstract
Age-related laterality and sub-system differences in the intrinsic functional connectivity of the default mode network
Journal of Cognitive Neuroscience. Supplement, Vol.2013, pp.109b-109b
01/01/2013
Abstract
Functional integration of the default mode degrades with aging. However, whether and how such changes relate to cognitive and behavioral functioning in older adults is not well understood. Recent evidence suggests that the DMN is comprised of two functionally distinct subsystems: a dorsal-medial prefrontal cortex (DMPFC) subsystem involved in self-oriented cognition and a medial temporal lobe (MTL) subsystem involved in memory and scene construction. Both subsystems interact with the posterior cingulate and the medial prefrontal regions that form the DMN core. The present study investigated age-related differences in intrinsic functional connectivity of these two subsystems. Participants (n = 60) were between the ages of 19-83 (mean = 46.3). Following previous work (Andrews-Hanna et al., 2010), a seed-based functional connectivity approached was used that corrected for small-scale motion. Functional connectivity within the right, but not left, core DMN regions negatively cor- related with age (r = -.26, p =.05). Additionally, there was an effect of aging on within, but not between, subsystem connectivity, suggesting no loss of specialization of the two DMN subsystems. Further, functional correlations between regions in the right MTL subsystem negatively correlated with age (r = -.29, p =.02), but this was not seen in the left MTL or either left or right DMPFC subsystem. Previous research has suggested that age-related cognitive decline might preferentially affect the right hemisphere (e.g., Dolcos et al., 2002). Our results are consistent with this within the DMN and further demonstrate MTL specificity for age-related DMN changes.
Details
- Title: Subtitle
- Age-related laterality and sub-system differences in the intrinsic functional connectivity of the default mode network
- Creators
- Amy BelfiMichelle Voss - University of Iowa, Iowa Neuroscience InstituteMerry Mani - University of Iowa, RadiologyChelsea WongGillian CookeMatthew SuttererRachel ClarkDaniel Tranel - University of Iowa, NeurologyEdward McAuleyArthur Kramer
- Resource Type
- Abstract
- Publication Details
- Journal of Cognitive Neuroscience. Supplement, Vol.2013, pp.109b-109b
- ISSN
- 1096-8857
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Neurology; Radiology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984071709102771
Metrics
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