Abstract
Allergic Sensitization and Enviromental Exposures In Amish and Hutterite Children
Journal of allergy and clinical immunology, Vol.133(2), pp.AB13-AB13
02/2014
DOI: 10.1016/j.jaci.2013.12.071
Abstract
Rationale
In separate studies of two US farming populations of central European ancestry, we found marked differences in the prevalence of allergic sensitization between Indiana Amish and South Dakota Hutterite children (7% vs. 40%). Here, we directly compared the prevalence of allergic sensitization and exposure to major inhaled allergens in these children.
Methods
30 age- and sex-matched school children each were studied in Nov (Amish) and Dec (Hutterite) 2012. Serum IgE (ImmunoCap; Phadia) to mite, cat, cockroach, mold, mouse urine protein and epithelium, mixed tree, and mixed grass allergens were measured. Atopy was defined as IgE>3.5KU/L to ≥1 allergen. Eight allergens (3 mite, cat, dog, cockroach, rat, mouse) were measured by multiplex immunoassay in airborne dust sampled from electrostatic dust collectors one month after their placement in 10 homes from each population.
Results
We confirmed atopy prevalence is 7% (2/30) among Amish and 30% (9/30) among Hutterite children (P=0.042). Common allergens were essentially undetectable in house dust from both groups, except for Mus m1, which was found more frequently (9 of 10 vs. 2 of 10 homes, P=0.0054) and at higher levels (median=210 vs. 15 ng/m2) in Amish compared to Hutterite homes. However, Amish children had no IgE to mouse allergens.
Conclusions
Differential exposure to common allergens per se does not explain the lower prevalence of allergic sensitization among Amish compared to Hutterite children. However, the combination of high mouse allergen exposure and lack of sensitization to these allergens may reflect a microbial environment that promotes protection from atopy among the Amish.
Details
- Title: Subtitle
- Allergic Sensitization and Enviromental Exposures In Amish and Hutterite Children
- Creators
- Mark Holbreich - Allergy and Asthma Consultants, Indianapolis, INMichelle Stein - University of ChicagoRebecca Anderson - University of ChicagoNervana Metwali - University of IowaPeter S. Thorne - University of IowaDonata Vercelli - University of ArizonaErika Von Mutius - University Children's Hospital, Munich, GermanyCarole Ober - University of Chicago
- Resource Type
- Abstract
- Publication Details
- Journal of allergy and clinical immunology, Vol.133(2), pp.AB13-AB13
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.jaci.2013.12.071
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Language
- English
- Date published
- 02/2014
- Academic Unit
- Occupational and Environmental Health; Civil and Environmental Engineering
- Record Identifier
- 9984638360302771
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