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Analysis of admissions due to Schistosoma mansoni influence over colorectal cancer admissions and mortality
Abstract   Peer reviewed

Analysis of admissions due to Schistosoma mansoni influence over colorectal cancer admissions and mortality

Gustavo Fernandes Godoy Almeida, Mauricio Assuero Lima de Freitas, Lais Neares, Maxwell Moura, Evandro Lopes de Barros Filho, Lauro Vinicius Machado da Silva, Mariana M M Lira, Ana Lucia Coutinho Domingues and Luiz Alberto Reis Mattos
Journal of clinical oncology, Vol.36(15_suppl), pp.e13602-e13602
05/20/2018
DOI: 10.1200/JCO.2018.36.15_suppl.e13602

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Abstract

Background: literature suggests a link between intestinal schistosomiasis and colorectal cancer. However, carcinogenesis promotion needs to be proven. This study aims to compare the incidence and mortality rates of colorectal cancer in cities with (Schistosoma + cancer cities - SCC) or without (cancer only cities – COC) diagnosis of schistosomiasis in Pernambuco (Northeast Brazil). Methods: DATASUS was used as database (Brazilian Ministry of Health) where hospital admissions, their diagnosis and mortality rates information is available. Odds ratio and relative risk were performed to test the null hypothesis that there were no difference between SCC and COC. Search was performed from January 2008 until November 2017. Results: In this period, there were 2444 admissions due to schistosomiasis in Brazil, 54.05% of them in the Northeast region. The state of Pernambuco registered 586 admissions, which correspond to 24.10% of the country and 44.45% of the region. In Brazil, a 39% decrease in the rate of hospitalizations due to schistosomiasis was observed from 2008 (2.20) in comparison to 2017 (1.33). In the same period, Pernambuco registered 10,524 admissions due to colorectal cancer (ADTCC) with an increase of 175% and an average growth of 9.93% per year from 2008 (4,78) to 2017 (12.32). One hundred one cities were categorized as SCC and 79 as COC. The mean rate of ADTCC in SCC was 94.55, with a variability of 366%, while in COC it was 11.06, with a variability of 88%. At a significance level of 5%, variance test rejected the hypothesis that the number of SCC and COC were similar (p-value, 0.0000), as well as ADTCC (p-value 0.0167) between SCC and COC. Data variability did not permit reliable conclusions about mortality. Conclusions: Despite the reduction in admissions due to schistosomiasis in Brazil in the last 10 years, the average rate of ADTCC in SCC were higher than in COC. This suggests that schistosomiasis may be a causal factor.

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