Abstract
Antiproliferative Natural Product Superstolide/ZJ‐101 Affects Cellular Adhesion in 3D Spheroid Model
The FASEB journal, Vol.33(S1), pp.504.3-504.3
04/2019
DOI: 10.1096/fasebj.2019.33.1_supplement.504.3
Abstract
The natural product known as Superstolide/ZJ‐101 has anti‐proliferative activity across a multitude of human cancer cell lines with an IC50 in the range of 30–100 nanomolar. Structure activity relationships have improved this activity to the single‐digit nanomolar range in 2D viability assays. Additionally, phenotypic assays have identified a strong cytostatic rather than cytotoxic effect. Recently ZJ‐101 has been tested in a 3D spheroid model of triple‐negative breast cancer to reveal a novel phenotype of cellular adhesion disruption. This effect has also been observed in 2D culture, indicating that both cell‐cell and cell‐substrate adhesion are similarly affected. Taken together, the anti‐adhesion phenotype could suggest a new type of cytostatic therapeutic which dissolves intractable tumors and prevents their migration, invasion and metastasis.
Support or Funding Information
NIH T32 Pharmacological Sciences Training Grant
This is from the Experimental Biology 2019 Meeting. There is no full text article associated with this published in The FASEB Journal.
Details
- Title: Subtitle
- Antiproliferative Natural Product Superstolide/ZJ‐101 Affects Cellular Adhesion in 3D Spheroid Model
- Creators
- Phillip R Sanchez - Johns Hopkins School of MedicineSarah A Head - Pharmacology & Molecular SciencesJohns Hopkins School of MedicineBaltimoreMDZhendong Jin - University of IowaJun O Liu - Pharmacology & Molecular SciencesJohns Hopkins School of MedicineBaltimoreMD
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.33(S1), pp.504.3-504.3
- Publisher
- The Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.2019.33.1_supplement.504.3
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH T32 Pharmacological Sciences Training Grant
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984366390202771
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