Abstract
ApoE−/−R+A+ Mice with Hypercholesterolemia, Hypertension, and Decreased Baroreflex Sensitivity Spontaneously Develop Heart Failure with Age
The FASEB journal, Vol.21(6), pp.A893-A893
2007
DOI: 10.1096/fasebj.21.6.A893
Abstract
We recently created a mouse model of combined hypercholesterolemia and hypertension (HT) by inter‐breeding apolipoprotein E deficient (ApoE−/−) and renin‐angiotensinogen transgenic (R+A+) mice. ApoE−/−R+A+ and R+A+ mice had similar mean blood pressure (BP) (156±2 and 153±4 mmHg at <25 wks of age), but the ApoE−/−R+A+ mice exhibited a much shorter lifespan (Clin Auton Res 15:2005). We hypothesized that high mortality in ApoE−/−R+A+ mice is related to development of heart failure with age. Cardiac function (echocardiography) and BP and heart rate (HR) (telemetry) were measured in 40–60 week old female mice. Spontaneous baroreflex sensitivity (BRS) was calculated using the sequence technique. Increased lung weight confirmed heart failure. R+A+ mice had HT and decreased BRS, but normal left ventricular ejection fraction (EF) and lung weight (Table). In contrast, ApoE−/−R+A+ mice were no longer HT at this age, but exhibited decreased BRS, decreased EF, and increased lung weight. (∗ vs. Control, † vs. R+A+, P<0.05).
BRS was also decreased in young (<25 wks) ApoE−/−R+A+ mice (0.97±0.2 vs. 1.90±0.3 ms/mmHg in controls) before development of heart failure. We conclude:
ApoE−/−R+A+ mice are HT in early adulthood, but HT dissipates as heart failure develops with age;
BRS is decreased at a young age in this model prior to heart failure and the impairment persists in the heart failure state despite reversal of HT.
(VA, HL14388)
Details
- Title: Subtitle
- ApoE−/−R+A+ Mice with Hypercholesterolemia, Hypertension, and Decreased Baroreflex Sensitivity Spontaneously Develop Heart Failure with Age
- Creators
- Rasna Sabharwal - Univ of IowaRobert M Weiss - Univ of IowaHarald M Stauss - Univ of IowaCurt D Sigmund - Univ of IowaFrancois M Abboud - Univ of IowaMark W Chapleau - Vet Aff Med Ctr
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.21(6), pp.A893-A893
- Publisher
- The Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.21.6.A893
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 2007
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984071959702771
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