Abstract
Association between functional small airways disease and 3-year change in emphysema in the SPIROMICS cohort
European respiratory journal, Vol.58(Suppl. 65), p.OA1283
09/05/2021
DOI: 10.1183/13993003.congress-2021.oa1283
Abstract
Background: Radiologic small airways disease is associated with subsequent emphysema increase.
Aim: Determine if this association is: a) seen as early as 3 years of follow-up; b) present in milder disease; c) modified by age.
Methods: We included SPIROMICS ever-smokers (88 normal spirometry; 139 GOLD 1-2 COPD; 43 GOLD 3-4 COPD) with thoracic CTs at enrollment and Year 3. Parametric Response Mapping was applied to co-registered inspiratory and expiratory CT images to measure the extent of functional small airways disease (PRMfSAD) and emphysema (PRMEmph) as % of total lung volume. We examined the association between baseline PRMfSAD (by 10% increments) and 3-year change in PRMEmph using linear regression models adjusted for age, sex, BMI, smoking status and baseline PRMEmph, and tested for interaction between baseline PRMfSAD and age.
Results: Mean age was 65.1±8.6 years (range 41-80), mean FEV1 was 77.3±23.3 % predicted, and 52.2% of participants were women. Medians (interquartile intervals) were 16.1% (5.7%-26.7%) for baseline PRMfSAD; 3.0% (1.0%-7.7%) for baseline PRMEmph; and 0.5% (0.03%-1.9%) for 3-year PRMEmph change. Baseline PRMfSAD was associated with 3-year increase in PRMEmph in all 270 participants (β=0.40; 95%CI 0.24-0.57; p<0.001) and the subgroup of 227 participants with normal or GOLD 1-2 spirometry (β=0.31; 95%CI 0.13-0.49; p<0.001). There was a significant interaction between PRMfSAD and age (β=-0.017; 95%CI -0.032 to -0.002; p=0.02) such that the association between PRMfSAD and increase in PRMEmph was stronger in younger individuals.
Conclusion: Early detection of radiologic small airways disease can help identify smokers at risk for emphysema progression.
Details
- Title: Subtitle
- Association between functional small airways disease and 3-year change in emphysema in the SPIROMICS cohort
- Creators
- Wassim W. Labaki - University of Michigan–Ann ArborCharles R. Hatt - ImbioAlexander J. BellCraig J. Galbán - University of Michigan–Ann ArborElla A. Kazerooni - University of Michigan–Ann ArborSusan Murray - University of Michigan–Ann ArborJeffrey R. Curtis - University of Michigan–Ann ArborFernando J. MartinezIgor Barjaktarevic - University of California, Los AngelesR. Graham Barr - Columbia UniversityRussell P. Bowler - National Jewish HealthAlejandro P. Comellas - University of IowaChristopher J. Cooper - University of California, Los AngelesDavid Couper - University of North Carolina at Chapel HillGerard J. Criner - Temple UniversityMark T. Dransfield - University of Alabama at BirminghamNadia N. Hansel - Johns Hopkins UniversityEric A. Hoffman - University of IowaRichard E. Kanner - University of UtahJerry A. Krishnan - University of Illinois at ChicagoVictor E. Ortega - Wake Forest UniversityRobert Paine - University of UtahPrescott G. Woodruff - University of California, San FranciscoMeiLan K. Han
- Resource Type
- Abstract
- Publication Details
- European respiratory journal, Vol.58(Suppl. 65), p.OA1283
- Publisher
- European Respiratory Society
- DOI
- 10.1183/13993003.congress-2021.oa1283
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Language
- English
- Date published
- 09/05/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Internal Medicine; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS
- Record Identifier
- 9984528114202771
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