Abstract
Association of the Portfolio Diet with Total and Cardiovascular Disease Mortality in the Women's Health Initiative
Annals of nutrition and metabolism, Vol.79(Suppl. 1), pp.337-338
08/01/2023
Abstract
Background and Objectives: The Portfolio Diet is a plant-based dietary pattern of established cholesterol-lowering foods. The diet has been shown to improve a number of cardiovascular disease (CVD) risk factors, including low-density lipoprotein cholesterol (LDL-C), blood pressure, and C-reactive protein (CRP) in clinical trials, and has been associated with lower CVD incidence in a prospective cohort. As yet, there have not been any large prospective studies directly assessing the relation of the Portfolio Diet to total and CVD mortality. Methods: We followed 109,445 postmenopausal women initially free of CVD, diabetes, and cancer in the Women's Health Initiative (WHI) Clinical Trials and Observational Study from 1993 to 2021. Adherence to the Portfolio diet was assessed using an a priori diet index based on six food categories (high in plant protein [soy & pulses], nuts, viscous fiber, phytosterols and monounsaturated fat, and low in saturated fat and dietary cholesterol) via a food frequency questionnaire at baseline and year three. Adjusted hazard ratios (HRs) and 95% confidence intervals [CIs] for CVD incidence and death and total mortality were calculated using Cox regressions, adjusted for potential confounders (including age, race/ethnicity, family history, lifestyle and dietary factors, and medication use). Results: Over a mean of 17.4 years of follow-up, there were 11,597 cases of incident total CVD, 4,695 cases of coronary heart disease (CHD), 4,215 cases of stroke, 7,624 cases of CVD death, and 28,162 total deaths. Comparing the highest to the lowest quartile in the fully adjusted model, higher adherence to the Portfolio diet was associated with a reduced risk of total CVD (HR=0.89 [95% CI 0.83-0.95]), CHD (0.85 [0.77-0.95]), CVD death (0.93 [0.86-1.01]), and total mortality (0.89 [0.85-0.92]). No association was found with stroke (1.03, [0.92-1.16]). Conclusions: In postmenopausal women, higher adherence to the Portfolio diet was inversely associated with total CVD, CHD, and total mortality, but not stroke. These prospective data provide the notion that the plant-based Portfolio diet may have direct benefits on CVD and mortality prevention in postmenopausal women.
Details
- Title: Subtitle
- Association of the Portfolio Diet with Total and Cardiovascular Disease Mortality in the Women's Health Initiative
- Creators
- Andrea GlennKenneth LoBeatrice BoucherMara VitolinsJoAnn MansonLinda SnetselaarCyril KendallDavid JenkinsSimin LiuJohn Sievenpiper
- Resource Type
- Abstract
- Publication Details
- Annals of nutrition and metabolism, Vol.79(Suppl. 1), pp.337-338
- Publisher
- S. Karger AG
- ISSN
- 0250-6807
- eISSN
- 1421-9697
- Comment
- IUNS 22nd International Congress of Nutrition – Abstracts. DOI: 10.1159/000530786
- Language
- English
- Date published
- 08/01/2023
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984460308402771
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