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Autonomic Stress Dysregulation in Temporomandibular Disorders with Multisystem Manifestation – A Pilot Feasibility Study
Abstract   Peer reviewed

Autonomic Stress Dysregulation in Temporomandibular Disorders with Multisystem Manifestation – A Pilot Feasibility Study

Hong Chen, Jennifer Sukalski, Mark W Chapleau and Steven Levy
The journal of pain, Vol.25(4 Supplement), pp.24-25
04/2024
DOI: 10.1016/j.jpain.2024.01.117

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Abstract

Temporomandibular disorders (TMD) are a major group of facial pain conditions that affects 12 million U.S. adults. Multisystem manifestations with co-existence of body pain disorders, psychological issues, and poor sleep quality are common in chronic TMD. Altered autonomic functions have been observed in individuals with multisystem manifestation prior to developing TMD. Because the autonomic abnormalities often precede organ system dysfunction, it is important to systemically evaluate autonomic functions in those with multisystem manifestations. The aim of this study was to develop and pilot test a protocol for autonomic function tests in TMD and controls. Autonomic functions of heart rate variability and cardiac impedance were evaluated during resting and challenging conditions (guided deep breathing, isometric sustained handgrip, and cold pressor). The protocol lasted for 60 minutes. Six females and 2 males participated the study. Range of age was 18-35. Four with TMD (4 with multisystem manifestation, 0 without), and 4 without TMD (2 with and 2 without multisystem manifestation). All participants completed the study protocol. No adverse events were observed. Data quality for baseline (rest) measures was good. Missing data in cardiac impedance presented in multiple participants during handgrip and cold pressor tests. These results indicated that the test protocol is feasible, but need improvement in handgrip and cold pressor tests. In addition, recruitment protocol needs to be improved for TMD without multisystem manifestation. Funded by University of Iowa College of Dentistry Seed Grant and Ohio State University College of Dentistry.

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